[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
About Journal::
Editorial Board::
Articles Archive::
Indexing Databases::
To Authors::
To Reviewers::
Registration::
Submit Your Article::
Policies and Publication Ethics::
Archiving Policy::
Site Facilities::
Contact Us::
::
Google Scholar Metrics

Citation Indices from GS

AllSince 2019
Citations709570
h-index1110
i10-index1512
..
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
Registered in

AWT IMAGE

AWT IMAGE

..
:: Volume 4, Issue 4 (9-2017) ::
2017, 4(4): 13-17 Back to browse issues page
The prevalence of chromosomal translocation t (1; 4) (p21; p14) in Iranian patients with mental disability
Pegah Vosoughi , Fatemeh Keshavarzi , Parviz Ashtari
Department of Biology, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran , gol.keshavarzi@gmail.com
Abstract:   (4542 Views)

Introduction: Intellectual disability or intellectual retardation is a condition in which total mental functioning is distinctively below average and there are disabilities in adaptive behaviors during growth. According to the definition of American Mental Disability Community in 1992 a person is considered intellectually disabled if he or she has an IQ (intelligence quotient) of less than 70 and has a limitation in one or multiple adaptive skills. There are many different causes of intellectual disability that one of them is the genetically and chromosomal abnormalities. The aim of this paper was to study translocation breakout t (1; 4) (p21; p14) in a number of mental retardation patients in Iran.

Materials and methods: This descriptive study was carried out on 100 persons with light mental disability by using cytogenetic methods. Lymphocytes were cultured in the dedicated environment by G-Banding karyotype of each person after obtaining patient’s blood sample. The data were statistically analyzed by logistic regression.

Results: The findings showed that none of the patients with a mental disability was afflicted to the chromosomal translocation, (1; 4) (p21; p14).

Conclusion: The lack of translocation in this study was equivalent with the obtained frequency in the same studies which have been carried out on the subjects suspected to have a translocation. Also, it seems that chromosomal analysis may be a usefulness diagnostic tool for children with mental retardation.

Keywords: Mental disability, Translocation, Karyotype
Full-Text [PDF 527 kb]   (1359 Downloads)    
Type of Study: Research | Subject: Genetics
Received: 2017/03/14 | Accepted: 2017/05/23 | Published: 2017/06/17
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA



XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Vosoughi P, Keshavarzi F, Ashtari P. The prevalence of chromosomal translocation t (1; 4) (p21; p14) in Iranian patients with mental disability . Journal of Basic Research in Medical Sciences 2017; 4 (4) :13-17
URL: http://jbrms.medilam.ac.ir/article-1-275-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 4, Issue 4 (9-2017) Back to browse issues page
مجله ی تحقیقات پایه در علوم پزشکی Journal of Basic Research in Medical Sciences
Persian site map - English site map - Created in 0.15 seconds with 40 queries by YEKTAWEB 4643