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Evaluation of PPP2R5C gene expression in Iranian patients with B-Acute lymphoblastic leukemia and its association with clinical and laboratory findings
Esmaeil Rostami, Hossein Ayatollahi, Hassan Boustani, Abbas Ghotaslou *, Mohammad Hadi Sadeghian, Mohammad Reza Keramati, Elahe Zeinali, Abolfazl Rad
Department of Hematology, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran , a.ghotaslou@gmail.com
Abstract:   (55 Views)

Introduction: PPP2R5C is one of the regulatory B subunits of protein phosphatase 2A (PP2A), which is a tumor suppressor. PPP2R5C plays a critical role in cell proliferation, differentiation, and transformation. Considering these vital functions, we investigate the gene expression in Iranian patients with B-Acute Lymphoblastic Leukemia (B-ALL) and its association with clinical and laboratory finding.

Materials and methods: In this case-control study, peripheral blood samples were collected from 60 B-ALL patients and 30 healthy controls. PPP2R5C expression levels were determined by Real-time PCR. After calculation of CT for target and control genes, we calculated ΔCT. Finally we compared the PPP2R5C expression levels in patients with control group.

Results: Significantly higher expression of PPP2R5C was found in the B-ALL patients (2.15±2. 50) compared with control group. There was no correlation between PPP2R5C expression and clinical and laboratory findings and FAB (French-American-British) subtype of patients.

Conclusion: we demonstrated PPP2R5C overexpression in B-ALL patients. Although there was no significant correlation between PPP2R5C expression, clinical and laboratory finding and also with FAB subtypes of patients.

Keywords: B-Acute Lymphoblastic Leukemia, PPP2R5C, PP2A, Gene expression
Full-Text [PDF 635 kb]   (55 Downloads)    
Type of Study: Research | Subject: Hematology
Received: 2017/02/22 | Accepted: 2017/04/21 | Published: 2017/06/15
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Rostami E, Ayatollahi H, Boustani H, Ghotaslou A, Sadeghian M H, Keramati M R, et al . Evaluation of PPP2R5C gene expression in Iranian patients with B-Acute lymphoblastic leukemia and its association with clinical and laboratory findings . JBRMS. 2017; 4 (4) :8-12
URL: http://jbrms.medilam.ac.ir/article-1-287-en.html
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مجله ی تحقیقات پایه در علوم پزشکی Journal of Basic Research in Medical Sciences
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