[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 7, Issue 1 (1-2020) ::
JBRMS 2020, 7(1): 50-60 Back to browse issues page
Effect of oleuropein and swimming practice on motor disorder induced by 6-hydroxydopamine toxin in mature male rats
Farzaneh Jafari , Abdolhassan Doulah , Maryam Rafieirad Dr
Department of Biology, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran , h_doulah@yahoo.com
Abstract:   (296 Views)
Introduction: Parkinsonchr('39')s disease is caused by damage to the nervous system. Oleuropein and exercise have protective effects on the nervous system. The purpose of the present study was to examine the effect of oleuropein and swimming practice on motor disorder induced by 6-hydroxydopamine toxin in mature male rats.
Materials and methods: In this experimental study, 40 rats were divided into control, Parkinsonchr('39')s, swimming practice (five sessions per week and 30 minutes per session), oleuropein (20mg/kg), and combined swimming practice and oleuropein groups. Parkinsonchr('39')s disease was induced by injection of 8μg 6-hydroxydopamine neurotoxin (6-OHDA) in the medial forebrain bundle (MFB) of the left brain of the rats. At the end of the administration period, catalepsy, step length, muscle stiffness, and motor coordination were measured using the rotarod test to assess motor disorders.
Results: Four weeks of oleuropein administration, four weeks of swimming practice, and four weeks of combined swimming practice and oleuropein use significantly improved the motor disorders induced by 6-OHDA administration. Moreover, four weeks of swimming practice and oleuropein showed a significant increase in motor balance test and a significant decrease in the rotarod test respectively compared to the administration of oleuropein (P<0.05). However, there was no significant difference in the swimming practice group.
Conclusion: The effects of swimming exercise, which is a high activity physical activity, were more tangible than those of oleuropein and did not show a significant difference with co-administration of oleuropein and swimming exercise, so it can be considered as an effective treatment for preventing the multiple complications of Parkinsonchr('39')s disease.
Keywords: Parkinson's disease, Oleuropein, Swimming practice, Motor disorder, 6-Hdroxydopamine
Full-Text [PDF 841 kb]   (70 Downloads)    
Type of Study: Research | Subject: Physiology
Received: 2020/01/15 | Accepted: 2020/03/19 | Published: 2020/01/10
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Jafari F, Doulah A, Rafieirad M. Effect of oleuropein and swimming practice on motor disorder induced by 6-hydroxydopamine toxin in mature male rats. JBRMS. 2020; 7 (1) :50-60
URL: http://jbrms.medilam.ac.ir/article-1-466-en.html


Volume 7, Issue 1 (1-2020) Back to browse issues page
مجله ی تحقیقات پایه در علوم پزشکی Journal of Basic Research in Medical Sciences
Persian site map - English site map - Created in 0.16 seconds with 32 queries by YEKTAWEB 4212