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2024, 11(1): 1-8 Back to browse issues page
Effect of Circuit Resistance Training on The Serum Levels of Myonectin and Lipid Profile in Young Men
Amirsam Heidarpour Ghiasi , Hamid Agha-alinejad , Maghsoud Peeri
Department of Physical Education & Sport Sciences, Faculty of Humanities, Tarbiat Modares University, Tehran, Iran , halinejad@modares.ac.ir
Abstract:   (513 Views)
Introduction: Myonectin is a key player in mediating lipid and glucose metabolism, and exercise training positively influences it by upregulating this myokine. However, the impact of different exercise regimens on myonectin levels is not well understood. This study aims to investigate the effects of three weeks of circuit resistance training on serum myonectin levels and lipid profiles in young men.
Material & Methods: Twenty sedentary young males (average age: 23.6 ± 3.2 years) participated, randomly assigned to circuit resistance training (n=10) and control (n=10) groups. Circuit resistance training, comprising nine sessions over three weeks with nine exercises per session at 60% of one-repetition maximum (1RM), was conducted. The control group maintained their daily routine. Blood samples, collected 48 hours post-training, underwent serum myonectin and lipid profile analysis using specialized kits. SPSS software version 24, ANCOVA tests (p < 0.05), were used for data analysis.
Results: The study revealed a significant increase in serum myonectin levels in the trained group compared to controls (p = 0.027). Additionally, the trained group exhibited a significant reduction in cholesterol and an increase in high-density lipoprotein (HDL) levels compared to controls (p < 0.05). Triglyceride and low-density lipoprotein (LDL) levels did not significantly change in the trained group compared to controls (p > 0.05).
Conclusion: This study demonstrates that short-term circuit resistance training (three weeks) significantly improves the lipid profile in sedentary subjects. The positive effect is partially attributed to the upregulation of myonectin levels induced by the training regimen.
Keywords: Exercise Training, Myokines, Lipid Profile
Full-Text [PDF 254 kb]   (158 Downloads)    
Type of Study: Research | Subject: Physiology
Received: 2023/03/27 | Accepted: 2023/04/3 | Published: 2024/01/20
References
1. Tremblay MS, Colley RC, Saunders TJ, Healy GN, Owen N. Physiological and health implications of a sedentary lifestyle. Appl Physiol Nutr Metab. 2010; 35(6):725-40. doi: 10.1139/H10-079.
2. Lavie CJ, Johannsen N, Swift D, Sénéchal M, Earnest C, Church T, et al. Exercise is medicine–the importance of physical activity, exercise training, cardiorespiratory fitness and obesity in the prevention and treatment of type 2 diabetes. Eur Endocrinol. 2014; 10(1):18-22. doi: 10.17925/EE.2014.10.01.18.
3. Braith RW, Stewart KJ. Resistance exercise training: its role in the prevention of cardiovascular disease. Circulation. 2006; 113(22):2642-50. doi: 10.1161/CIRCULATIONAHA.105.584060.
4. Ahima RS, Park HK. Connecting myokines and metabolism. Endocrinol Metab. 2015; 30(3):235-45. doi: 10.3803/EnM.2015.30.3.235.
5. Pedersen L, Hojman P. Muscle-to-organ cross talk mediated by myokines. Adipocyte. 2012; 1(3):164-7. doi: 10.4161/adip.20344.
6. Görgens SW, Eckardt K, Jensen J, Drevon CA, Eckel J. Exercise and regulation of adipokine and myokine production. Prog Mol Biol Transl Sci. 2015; 135:313-36. doi: 10.1016/bs.pmbts.2015.07.002.
7. Severinsen MC, Pedersen BK. Muscle–organ crosstalk: the emerging roles of myokines. Endocr Rev. 2020; 41(4):594-609. doi: 10.1210/endrev/bnaa016.
8. Iizuka K, Machida T, Hirafuji M. Skeletal muscle is an endocrine organ. J Pharmacol Sci. 2014; 125(2):125-31. doi: 10.1254/jphs.14r02cp.
9. Schäffler A, Buechler C. CTRP family: linking immunity to metabolism. Trends Endocrinol Metab. 2012; 23(4):194-204. doi: 10.1016/j.tem.2011.12.003.
10. Seldin MM, Wong GW. Regulation of tissue crosstalk by skeletal muscle-derived myonectin and other myokines. Adipocyte. 2012; 1(4):200-2. doi: 10.4161/adip.20877.
11. Seldin MM, Peterson JM, Byerly MS, Wei Z, Wong GW. Myonectin (CTRP15), a novel myokine that links skeletal muscle to systemic lipid homeostasis. J Biol Chem. 2012; 287(15):11968-80. doi: 10.1074/jbc.M111.336834.
12. Pourranjbar M, Arabnejad N, Naderipour K, Rafie F. Effects of aerobic exercises on serum levels of myonectin and insulin resistance in obese and overweight women. J Med Life. 2018 Oct;11(4):381. doi: 10.25122/jml-2018-0033.
13. Rodríguez A, Becerril S, Ezquerro S, Mendez‐Gimenez L, Frühbeck G. Crosstalk between adipokines and myokines in fat browning. Acta physiol. 2017; 219(2):362-81. doi: 10.1111/apha.12686.
14. Vosadi E, Ravasi AA, Soori R, Mazaheri Z, Shabkhiz F. The effect of 4 weeks of endurance exercise on the expression of the muscle Myonectin levels and Insulin resistance in the adult rat. Pathobiol Res. 2016; 19(2):89-97 [Persian].
15. Safarzade A, Moazam-Vahid L. Effect of eight weeks resistance training on plasma myonectin concentration in obese men. J Appl Exerc Physiol. 2016; 12(24):119-28. doi:10.22080/JAEP.2017.1466 [Persian].
16. Kazemi A, Mizani R. The comparison of different order of concurrent training on plasma myonectin levels, insulin resistance index and anthropometric characteristics of elderly women. EBNESINA 2015; 16 (4) :39-46 [Persian].
17. Adigozalpour M, Safarzade A. Effect of resistance training with two different volumes on serum myonectin levels in rats fed with sucrose solution. Ann Appl Sport Sci. 2017; 5(2):11-9. doi: 10.18869/acadpub.aassjournal.5.2.11.
18. Choi HY, Park JW, Lee N, Hwang SY, Cho GJ, Hong HC, et al. Effects of a combined aerobic and resistance exercise program on C1q/TNF-related protein-3 (CTRP-3) and CTRP-5 levels. Diabetes Care. 2013; 36(10):3321-7. doi: 10.2337/dc13-0178.


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