AU - Maleki, Farajolah AU - Azizian, Mitra AU - Shohani, Masoumeh AU - Amraei, Mansour TI - Investigating the prevalence of FXIIIVal34Leu polymorphism in the thalassemic patients of Ilam City PT - JOURNAL ARTICLE TA - Ilam-University-of-Medical-Sciences JN - Ilam-University-of-Medical-Sciences VO - 2 VI - 1 IP - 1 4099 - http://jbrms.medilam.ac.ir/article-1-100-en.html 4100 - http://jbrms.medilam.ac.ir/article-1-100-en.pdf SO - Ilam-University-of-Medical-Sciences 1 ABĀ  - Introduction: The coagulation factor 13 has a fundamental role in homeostasis, protective effects on thrombosis, and some other associated diseases. Due to increasing the chronic coagulability of major thalassemic patients, this study was conducted with aim determining the prevalence of Val34LeuFXIII polymorphism in the thalassemic patients. Materials and methods: The present case-control study was conducted on 100 patients with major thalassemia with a gender ratio of 50 females and 50 males as case and 100 healthy persons as control with a gender combination of 50 males and 50 females that were selected with the referral order on the different days. DNA extraction and the polymerase chain reaction (PCR) were conducted. The genotypes of this polymorphism were identified by RFLP technique and Cfo1 restrictive enzyme. The analysis of data was conducted by SPSS 11.5 software, chi-square, and logistic regression statistical tests. P CP - IRAN IN - LG - eng PB - Ilam-University-of-Medical-Sciences PG - 9 PT - Research YR - 2015