TY - JOUR T1 - The effect of aerobic exercise and a synthesized insulin nanocomposite hydrogel on TNF-α and IL-6 in plasma of type 1 diabetic rats TT - JF - Ilam-University-of-Medical-Sciences JO - Ilam-University-of-Medical-Sciences VL - 7 IS - 2 UR - http://jbrms.medilam.ac.ir/article-1-437-en.html Y1 - 2020 SP - 38 EP - 46 KW - Aerobic training KW - Synthesized insulin nanocomposite hydrogel KW - TNF-α KW - IL-6 KW - Type 1 diabetic rat N2 - Introduction: Diabetes is one of the leading causes of mortality in the world. The present study aimed to investigate the effect of aerobic exercise training and a synthesized insulin nanocomposite hydrogel on TNF-α and IL-6 in type 1 diabetic rats. Materials and methods: Twenty-five rats were divided into five equal groups of animals each containing five animals, control - healthy, Control-diabetes, Nano-insulin Diabetes, Exercise Diabetes and Nano-insulin Diabetes-Exercise. The exercise training program lasted eight weeks. After the five days of familiarization, exercise time for the exercise groups were as follows: 20 m/min for the first and second weeks, 25 m/min for the third and fourth weeks and 30 m / min for the fifth and sixth weeks. The rats were also given the Nano-insulin supplement. Rats were killed 48 hours after the last training session. Their plasma was taken and used for the analysis of markers. Results: There were significant differences in IL-6 (P<0.001) and TNF-α (P<0.001) between the groups. Conclusion: The results of this study showed that aerobic exercise training along with Nano-insulin supplementation significantly reduced TNF-α and IL-6 in rats with type 1 diabetes and these changes were more in the Nano-insulin Diabetes group. M3 ER -