Journal of Basic Research in Medical Sciences
مجله ی تحقیقات پایه در علوم پزشکی
Journal of Basic Research in Medical Sciences
Medical Sciences
http://jbrms.medilam.ac.ir
1
admin
2383-0506
2383-0972
doi
en
jalali
1396
12
1
gregorian
2018
3
1
5
2
online
1
fulltext
en
Decreased level of the anti-inflammatory adipokines, secreted frizzled-related protein 5 and adiponectin, in high cholesterol diet-induced atherosclerotic rats
Physiology
Physiology
پژوهشي
Research
<div><strong>Introduction:</strong> The involvement of secreted frizzled-related protein5 (SFRP5) and adiponectin, two important adipokines produced by adipocytes, in cardiovascular diseases demand further assessment. Therefore, in this study the relation of the adipokines and atherosclerosis was evaluated in Rat.<br>
<strong>Materials and methods: </strong>For the study, thirty male Wistar rats were divided into 2 groups (each group contain 15 rats): Control group, received a normal diet and the high cholesterol diet (HCD) group which received an additional 2% cholesterol and 0.5% cholic acid for 15 weeks. At the end of treatment, HCD-induced atheroma plaques were observed by hematoxylin and eosin staining of aortic tissue sections. Furthermore, serum levels of SFRP5 and adiponectin in the two groups of rats were measured by immunoassay and their relationships with the development of atherosclerotic plaques in the experimental group were analyzed.<br>
<strong>Results: </strong>The serum level of SFRP5 and adiponectin was significantly decreased in HCD rats compared with the control group (P<0.05). There was also an inverse relation between the serum level of the two adipokines and atherosclerotic plaque formation (P<0.05). </div>
<strong>Conclusion: </strong>Serum levels of SFRP5 and adiponectin are decreased in rats fed with high cholesterol diet, highlighting the involvement of the two adipokines in atherosclerosis.
High cholesterol diet, Atherosclerotic plaque, Adiponectin, SFRP5, Rat
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38
http://jbrms.medilam.ac.ir/browse.php?a_code=A-10-325-1&slc_lang=en&sid=1
Aghdas
Gharibi
shemshad_61000@yahoo.com
10031947532846002852
10031947532846002852
No
Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
Parichehr
Yaghmaei
yaghmaei_p@srbiau.ac.ir
10031947532846002853
10031947532846002853
Yes
Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
Gholam
Basati
basati-gh@medilam.ac.ir
10031947532846002854
10031947532846002854
No
Biotechnology and Medicinal Plants Research Center, Ilam University of Medical Sciences, Ilam, Iran
Kourosh
Soleimannejad
10031947532846002855
10031947532846002855
No
Department of Cardiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran
Naser
Abbasi
ilamfarma@gmail.com
10031947532846002856
10031947532846002856
No
Biotechnology and Medicinal Plants Research Center, Ilam University of Medical Sciences, Ilam, Iran