Journal of Basic Research in Medical Sciences
مجله ی تحقیقات پایه در علوم پزشکی
Journal of Basic Research in Medical Sciences
Medical Sciences
http://jbrms.medilam.ac.ir
1
admin
2383-0506
2383-0972
doi
en
jalali
1396
12
1
gregorian
2018
3
1
5
2
online
1
fulltext
en
Antifungal agents: Polyene, azole, antimetabolite, other and future agents
Pharmacology
Pharmacology
مقالات مروری
Review Article
<div>Antifungals have always been considered as one of the astonishing discoveries of the 20th century. This is correct, but the real marvel is the development of antifungal resistance in hospitals, communities, and the environment concomitant with their use. Fungal infections have emerged as an important clinical threat, with significant associated morbidity and mortality. This study is designed to provide a comprehensive view of antifungal agents and related agents. Information was based on the expertise of some literatures. Over the past decades, the incidence and diversity of fungal infection has grown in association with an increasing number of immunocompromised patients. An understanding of the pharmacokinetic and pharmacodynamics properties of the classes of antifungal compounds is vital for the effective management of invasive fungal infections. This review provides a summary of the pharmacologic principles involved in treatment of fungal diseases. Clinical needs for novel antifungal agents have altered steadily with the rise and fall of AIDS-related mycoses, and the change in spectrum of fatal disseminated fungal infections that has accompanied change in therapeutic immunosuppressive therapies.</div>
Antifungal agents, Future agents, Polyenes, Azole
48
55
http://jbrms.medilam.ac.ir/browse.php?a_code=A-10-337-1&slc_lang=en&sid=1
Fardin
Ali Malayeri
falimalayeri@gmail.com
10031947532846003010
10031947532846003010
No
Department of Clinical Biochemistry, Faculty of Medicine, Zabol University of Medical sciences, Zabol, Iran
Aliakbar
Rezaei
rezaei.aliakbar85@gmail.com
10031947532846003011
10031947532846003011
No
Department of Pathobiology, Faculty of Veterinary Medicine, Shahid Bahonar University of Kerman, kerman, Iran
Omid
Raiesi
omid_raissi69@yahoo.com
10031947532846003012
10031947532846003012
Yes
Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran