Journal of Basic Research in Medical Sciences
مجله ی تحقیقات پایه در علوم پزشکی
Journal of Basic Research in Medical Sciences
Medical Sciences
http://jbrms.medilam.ac.ir
1
admin
2383-0506
2383-0972
doi
en
jalali
1397
6
1
gregorian
2018
9
1
5
4
online
1
fulltext
en
Association of low serum level of secreted frizzled-related protein 5 (SFRP5) with the presence and severity of coronary artery disease
Biochemistry
Biochemistry
پژوهشي
Research
<div><strong>Introduction:</strong> Secreted frizzled-related protein 5 (SFRP5), an anti-inflammatory adipokine, is excreted by adipose tissue and may have protective effects on cardiovascular system. In the present study, the relationships of serum level of SFRP5 with the presence and severity of coronary artery disease (CAD) was investigated. <br>
<strong>Materials and methods:</strong> In the current study, 40 control subjects, 40 stable and 40 unstable CAD patients were included. Serum level of SFRP5 in all subjects in the study was determined by immunoassay method. The severity of CAD (based on Gensini score) was assigned by angiography examination. The status of conventional risk factors was also determined. Then, the association of SFRP5 with CAD severity and traditional CAD risk factors was explored<span dir="RTL">.</span><br>
<strong>Results:</strong> Serum level of SFRP5 was lowest in unstable CAD, followed by stable CAD patients and then control subjects (P < 0.001). The correlation of SFRP5 with Gensini score was significant only in unstable CAD patients (P < 0.01). However, the correlation of SFRP5 with the traditional CAD risk factors was relatively significant and negative in all patients (P<0.05). SFRP5 had a reverse association with the presence of CAD<span dir="RTL">.</span></div>
<strong>Conclusions:</strong> Decreased level of serum SFRP5 is associated with the presence and severity of CAD, highlighting its usefulness as a potential clinical biomarker.
SFRP5, Unstable CAD, Coronary artery diseases
35
40
http://jbrms.medilam.ac.ir/browse.php?a_code=A-10-348-1&slc_lang=en&sid=1
Safoura
Abdi
divin_2020@yahoo.com
10031947532846003081
10031947532846003081
Yes
Department of Biology, Tehran Shargh Branch, University of Payame Noor, Tehran, Iran
Gholam
Basati
basati-gh@medilam.ac.ir
10031947532846003082
10031947532846003082
No
Clinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam, Iran