Journal of Basic Research in Medical Sciences
مجله ی تحقیقات پایه در علوم پزشکی
Journal of Basic Research in Medical Sciences
Medical Sciences
http://jbrms.medilam.ac.ir
1
admin
2383-0506
2383-0972
doi
en
jalali
1397
12
1
gregorian
2019
3
1
6
2
online
1
fulltext
en
Antibiotic resistance of Citrobacter freundii in clinical isolates: A systematic review and meta-analysis
Microbiology
Microbiology
مقالات مروری
Review Article
<div><strong>Introduction: </strong><em>Citrobacter freundii</em> (<em>C. freundii</em>) is an opportunistic infection agent in hospitalized patients, especially in the intensive care units (ICUs). The prevalence of antibiotic resistance in <em>C. freundii</em> is increasing in the worldwide, and this may cause significant clinical problems. This paper aims at evaluating the rate of antibiotic resistance of <em>C. freundii</em> using meta-analysis.<br>
<strong>Materials and methods: </strong>A total of eight qualified antibiotics in 21 published articles were chosen randomly to estimate the antibiotic resistance percentage of <em>C. freundii</em> in different countries. The data were analyzed by meta-analysis (random effect model) and the heterogeneity was determined using Cochran’s Q and I<sup>2</sup> index. Also, Forest plot with confidence interval 95% were attained by R software.<br>
<strong>Results: </strong>Our data showed that the antibiotic resistance pattern of <em>C. freundii</em> in different parts of the world was not absolutely same but the maximum range of resistance was related to gentamicin and the minimum range of resistance was related to imipenem. Q and I<sup>2 </sup>were attained 45.25 (P<0.05) and 56%, respectively.<br>
<strong>Conclusion: </strong>The findings of this study showed that the variability in antibiotic resistance pattern of <em>C. freundii</em> in different studies across the world was due to heterogeneity in hygiene level that resulted from various geographic regions.</div>
Citrobacter freundii, Antibiotic resistance, Nosocomial pathogen
58
63
http://jbrms.medilam.ac.ir/browse.php?a_code=A-10-355-2&slc_lang=en&sid=1
Arman
Rostamzad
arostamzad381@yahoo.com
10031947532846003320
10031947532846003320
No
Department of Biology, Faculty of Basic Science, Ilam University, Ilam, Iran
Aboozar
Karami Cherag Abad
akerami.95@gmail.com
10031947532846003321
10031947532846003321
No
Department of Biology, Faculty of Basic Science, Ilam University, Ilam, Iran
Mehdi
Omidi
omidi_280@yahoo.com
10031947532846003322
10031947532846003322
Yes
Department of Mathematics, Ilam University, Ilam, Iran
Aliasghar
Hatamnia
hatamniya60@gmail.com
10031947532846003323
10031947532846003323
No
Department of Biology, Faculty of Basic Science, Ilam University, Ilam, Iran