1 2383-0506 ilam university of medical sciences 153 Gynecology The vasomotor symptoms and skin changes in natural menopause among Iranian women Shohani Masoumeh b Rasouli Mahboobeh c Shohani Fatemeh d Sayehmiri Kourosh e b Department of Nursing, Faculty of Allied Medical Sciences, Ilam University of Medical Sciences, Ilam, Iran c Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran d Department of Psychology, Velayat First High School, Ilam, Iran e Department of Biostatistics, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran 1 3 2016 3 2 1 10 28 06 2015 26 08 2015 Introduction: Menopause is the most important event in middle-age. Women, in this period, face several changes. Vasomotor symptoms and skin changes are prevalent in the middle-age. This study, mainly, was performed identifying the vasomotor symptoms and skin changes in menopausal women. Materials and methods: Study sample was consisted of 150 women who have visited the healthcare centers, experienced natural menopause as discontinuity of menstrual at least for 12-monthes. They have been selected randomly. Survey instruments were structured questionnaire, informational records, symptoms and signs checklist, centi-meter and balance and the data collecting method was through interview, observation, and examination. The data were analyzed using logistic regression. Results: According to study results, skin warming and hotness (55.3%), hands and legs nipping (63.3%), hirsutism of pinion lip (27.3%), reduction of armpit hair (38%), acne (12%), Skin extenuation and wrinkling (51.3%) were reported. The most important point of the study is the significant relationship between amount of tea consumption and flushing severity (P=0.008, OR=3.18). Also, there was a significant relation between education and menopause duration, sleep disorders and severity of flushing, menopause duration and skin collagen reduction (P<0.05). Conclusion: Skin and vasomotor changes is prevalent in these women. Flushing severity influenced by tea consumption, such that drinking more tea will decrease the flushing, is the start point of more researches in this field.
189 Hematology Expression of BCL2L12 in acute leukemia patients: Potential association with clinical and prognostic factors Boustani Hassan f Ayatollahi Hossein g Rahimi Hossein h Boroumand-Noughabi Samaneh i Gharib Masoumeh j Alidadi Mohammad k Shajiei Arezoo l Sadeghian Mohammad Hadi m f Department of Lab Sciences, Faculty of Allied Medical Sciences, Ilam University of Medical Sciences, Ilam, Iran g Department of Hematology and Blood Bank, Cancer Molecular Pathology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran h Department of Internal Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran i Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran j Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran k Cancer Molecular Pathology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran l Cancer Molecular Pathology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran m Department of Hematology and Blood Bank, Cancer Molecular Pathology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran 1 3 2016 3 2 11 19 16 09 2015 16 11 2015 Introduction: Apoptosis is an important mechanism in both physiological and pathological conditions. The BCL2 family of proteins plays a critical role in regulation of apoptotic cell death. Up and down regulation of BCL2-like 12 (BCL2L12), a new member of the BCL2 family, has been reported in several malignancies. However, the expression level of BCL2L12 rarely has been studied in leukemia. This study was designed to investigate the mRNA expression of BCL2L12 in patients with acute leukemia. Materials and methods: 90 patients with acute leukemia as case group and 90 healthy persons as controls, were participated this study. RNA was extracted from peripheral blood samples. Expression level of BCL2L12 mRNA was evaluated by a quantitative real-time polymerase chain reaction (qRT-PCR) method and its association with clinical and laboratory findings was analyzed. Results: The expression of BCL2L12 mRNA was significantly lower in acute lymphoblastic leukemia (ALL) cases comparing the controls (P<0.001), while it was not significantly different in acute myeloid leukemia (AML) samples compared the control group. In addition, there were higher BCL2L12 level in females (than in males) and in patients with t(1221) in ALL patients. There was no association between BCL2L12 expression level and other clinical and laboratory findings of AML patients. Conclusion: BCL2L12 seems play a role in the pathogenesis of ALL.  Further studies with larger sample size is needed to clarify its probable impact on prognosis and therapeutic response. 117 Psychology Investigating the relationship between personality characteristics, self-control, and general health among the students of public and clinical psychology in Islamic Azad University of Ilam Mousavi Moghadam Seyed Rahmatollah n Malekian Somayeh o Karamshahi Maryam p n Department of Islamic Theology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran o Department of Psychology, Research and Sciences Branch, Islamic Azad University, Ilam, Iran p Department of Psychology, Research and Sciences Branch, Islamic Azad University, Ilam, Iran 1 3 2016 3 2 20 25 22 04 2015 02 12 2015 Introduction: Mental health is a branch of science focused on promoting welfare, social welfare, and life health which is related to all periods (from birth to death) and aspects of life (family environment, school, university, appointment, and society). Personality is a collection of mental characteristics that consistently exists within individuals and influences their behaviors and thoughts. Self-control as one of the unique personality characteristics varies from one person to another. Materials and methods: The present study is a correlational descriptive study. The target population of this research includes all graduate students of public and clinical psychology studying in Islamic Azad University of Ilam during academic year of 93-94. According to statistics there were approximately 536 students in this field. Out of this number 224 students were selected through simple random sampling. Measurement instruments included: Tangney and Baumeister (2004) Self-Control Scale, NEO Five-Factor Inventory, and Goldberg General Health Questionnaire. For the analysis of findings of this study Kalmogorov–Smiranov test, correlation, and regression analysis were run through statistical software of SPSS. Results: Results of this research showed that personal characteristics and self-control predicted 86% of variance that is, significantly predicted the level of mental health among students. Results of correlation revealed significant relationship between self-control and mental health. In addition, there were significant relation between personality traits and self-control. In other words,   it can be said that personality characteristics have a substantial role in predicting mental health and there is also significant relationship between the variables under study. Conclusion: It can be said that self-control is one of the most important personality characteristics that influences individuals’ mental health. 64 Nursing The prevalence of elder abuse and associated factors among the elderly in Kashan city, Iran khalili Zahra Taghadosi Mohsen Gilasi Hamidreza Sadrollahi Ali Department of Nursing, Faculty of Medical Sciences, Ardabil University of Medical Sciences, Ardabil, Iran Department of Nursing, Faculty of Medical Sciences, Kashan University of Medical Sciences, Kashan, Iran Department of Epidemiology and Biostatistics, Kashan University of Medical Sciences, Kashan, Iran 4. Department of Clinical Affairs, Golestan University of Medical Sciences, Gorgan, Iran 1 3 2016 3 2 26 34 28 11 2014 29 08 2015 Introduction: Elder abuse is among the major social health problems in today`s communities, and has significant effect on decreasing the health and security level in this group. The current study aimed to evaluate the prevalence and associated factors of abuse among the elderly in Kashan, Iran. Materials and methods: This cross sectional study was conducted on 500 people over 60 years old in Kashan, Iran in 2014. Subjects were randomly selected from 10 healthcare centers of Kashan. Data were collected using elder abuse questionnaire. Cronbach alpha coefficient of the questionnaire was determined as 0.975. Data were analyzed by SPSS version 13. Pearson correlation coefficient and logistic regression analysis were used for data analysis. The statistically significant level was P<0.05. Results: Results of the current study showed that 80% of subjects have experienced at least one type of abuse during the last year. The highest rate of abuse was in the form of financial abuse (45.6%), and the lowest was in ostracizing (16.6%). There was a statistical significant relationship between the elder abuse and variables such as sex, age, number of children, marital status, living arrangement, residential situation, home properties, monthly income, insurance situation, illness history, walking ability and using mobility aids. Logistic regression analysis also showed significant relationship between the elder abuse and unemployment, living in an apartment, and the age range 71-80 years. Conclusion: Considering the high prevalence of abuse among the elderly, clarification of this phenomenon is considered as one of the main priorities, which can be achieved only through multidisciplinary approach in the community, and needs cooperation and collaboration of all community members. 190 Microbiology Correlation of 16s rRNA with serum levels of the cytokines, TNF-α and IL-1β, in subjects with a positive Helicobacter pylori Stool Antigen test (HPSA) Moradipour Ayat Khosravi Afra Mehrabi Mohamadreza Faryadian Sara Department of Microbiology, Borujerd Branch, Islamic Azad University, Borujerd, Iran Department of Immunology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran Department of Laboratory Sciences, Borujerd Branch, Islamic Azad University, Borujerd, Iran Department of Physiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran 1 3 2016 3 2 35 40 16 07 2015 17 09 2015 Introduction: Helicobacter pylori (H. pylori), is a bacterium responsible for upper gastrointestinal tract diseases. The 16s rRNA is a common H. pylori gene which are usually preferred for diagnosis purpose. The aim of this study was to determine the prevalence and abundance of 16s rRNA in fecal samples and also evaluate correlation between the level of 16s rRNA and activities of the cytokines, TNF-&alpha and IL-1&beta, in serum. Materials and methods: The present study was performed on 84 subjects with digestion problems. Fecal and blood samples were collected and 16s rRNA gene was assayed using PCR. The serum levels of TNF-&alpha and IL-1&beta levels were measured by enzyme-linked immunosorbent assay (ELISA). Results: The results of the study revealed that there was a positive correlation between the 16s rRNA gene, H. pylori stool antigen (HPSA) and TNF-&alpha cytokine. The study also noted that with every unit of increase in either of the quantified parameters of HPSA and IL-1&beta, the presence of 16s rRNA in fecal samples, showed a 2.98 and 1.01 times rise, respectively. Conclusion: According to the obtained results, it may be concluded that activities of cytokine TNF-a correlated well with the presence of HPSA and 16srRNA gene in the stomach’s lining. Increase in the activities of HPSA and TNF-a cytokine could be associated with the presence of 16s rRNA in feces. 106 Medical Anatomy Investigating the prevalence of congenital anomalies and its associated factors in Ilam city Sayehmiri Kourosh Kaffashian Mohammad Reza Ranaei Elahe Research Center for Prevention of Psychosocial trauma, Ilam University of Medical Sciences, Ilam, Iran Department of Physiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran Department of Anatomy, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran 1 3 2016 3 2 41 45 08 04 2015 28 06 2015 Introduction: Congenital anomalies are a common cause of disability and mortality in newborns and their treatments involves high costs for the society. This study aimed to investigate the prevalence of congenital anomalies and their causes. Materials and methods: This research was a descriptive-analytical study and the population included all the newborns in hospitals of the city of Ilam in 2011. Variables of abnormality type, birth status, and medical and genetic illness histories were included into the data collection forms. Data was analyzed through Chi-square tests and Fisher;#39s exact test using SPSS software. Results: Of 460 neonates, 5.4 percent (25 cases) had died at birth and 3.7 percent (16 infants) were born with a birth defect. 43.8 percent of malformed babies had a family history. 31.3 % of the malformed babies had genetic syndromes, whose parents had consanguineous marriage. 18.8% of babies with defects in the central nervous system and cardiovascular system showed a similar percentage of disorder. The defect in the urinary system, head and neck each accounted for 12.5 percent. Conclusion: This study shows that consanguineous marriages can be the most common genetic cause of genetic syndromes. 151 Health education Effect of educational intervention on practice improvement of employees in healthcare centers and meat distribution centers of Ilam province about Crimean Congo hemorrhagic fever Mokhtari Fariba Sharifinia Narges Mokhtari Zahra Qorbani Mostafa Shafieyan Hadad astgari Mehr Babak R Mirzai Amin Shafieyan Zahra Mansourian Morteza Department of Public Health, Faculty of Health, Ilam University of Medical Sciences, Ilam, Iran Department of Public Health, Faculty of Health, Ilam University of Medical Sciences, Ilam, Iran Department of Clinical Pathobiology, Azad University, Sanandaj, Iran Departments of Community Medicine, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran Department of Pathobiology, Faculty of Veterinarian, Shahid Chamran University, Ahvaz, Iran Department of Public Health, Faculty of Health, Abadan School of Medical Sciences, Abadan, Iran Department of Public Health, Faculty of Health, Ilam University of Medical Sciences, Ilam, Iran Student Research Committee, Ilam University of Medical Sciences, Ilam, Iran Department of Public Health, Faculty of Health, Ilam University of Medical Sciences, Ilam, Iran 1 3 2016 3 2 46 52 27 06 2015 06 09 2015 Introduction: Crimean Congo hemorrhagic fever (CCHF) is a Zoonosis disease. The aim of this study was to examine the effect of educational intervention on practice improvement of employees in healthcare centers and meat distribution centers of Ilam province in relation to Crimean Congo hemorrhagic fever. Materials and methods: Participants in present quasi-experimental study were 200 employees of healthcare centers and 75 workers of meat distribution centers that were selected through simple random sampling. Data were collected at baseline and 6-weeks after intervention using two 38-item and 50-item questionnaires. Data were analyzed by the SPSS software. P<0.05 were considered to be statistically significant. Results: Before the educational intervention, 20.6% of the healthcare centers employees had poor knowledge, 61.8% and 17.6% had average and good knowledge, respectively. After educational intervention, these percentages were 2%, 22.1% and 76% in that order. The workers’ knowledge level in centers of meat processing-distribution before training was 64% poor, 34.7% average, and 1.3% good but after education, the knowledge levels reached to 5.3%, 45.3% and 49.3% respectively (P<0.05). Moreover, Attitude of employees in healthcare centers and meat distribution centers significantly increased after intervention (P<0.05). But, there were not significant changes in performance of two groups before and after educational intervention Conclusion: The results of present study showed the effect of educational intervention on improvement the knowledge, attitude of employees in healthcare and meat distribution centers. So, implementation of an educational program for employees at a wider scale could promote their health. 161 Genetics A survey of patients with mental retardation of unknown origin Yarmohammadi Afshin Keshavarzi Fatemeh Farhadian Mokhtar Department of Biology, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran Department of Biology, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran Department of Psychology, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran 1 3 2016 3 2 53 57 06 07 2015 22 10 2015 Introduction: Fragile X syndrome (FXS) is one of the most prevalent genetic causes of developmental disability, representing the most frequent form of inherited severe cognitive deficit. The present study was undertaken to investigate FXS and its prevalence in moderate mentally retarded people in patients. Materials and methods: Nineteen people with moderate mental retardation (MR) who were clinically suspicious to have FXS were screened for FXS by using cytogenetic and molecular methods. Blood samples were collected and cultured in specific culture media. G-Banding method was used for karyotyping. To ensure correct results of cytogenetic testing, four suspected case of FXS were tested by PCR. Results were analyzed using logistic regression analysis. Results: Four patients (4%) were found to express fragile X site at q27.3. The results showed that the relationship of FXS with familial, economic status was not significant, but the relationship of FXS with MR and family history was significant. Conclusion: The frequency of FXS positive cases found in this study is similar to other reports of FXS in preselected patients.