en Hematology Hematology پژوهشي Research <p data-end="137" data-start="108"><span style="font-size:9pt"><span minion="" pro="" style="font-family:"><b>Introduction</b>: Eosinophils are inflammatory cells that perform diverse functions and play roles in both homeostasis and disease in various tissues. Evidence indicates that many patients with chronic respiratory conditions, including asthma and COPD, exhibit persistent eosinophilic airway inflammation. This study aimed to evaluate the prevalence of blood eosinophilia in patients with obstructive patterns on spirometry.</span></span><br> <span style="font-size:9pt"><span minion="" pro="" style="font-family:"><b>Materials & Methods</b><b><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times="">: </span></span></b>This cross-sectional study was conducted on patients attending the Hazrat Rasoul Akram Hospital, affiliated with Iran University of Medical Sciences. Patients who underwent spirometry and had peripheral blood tests were included in the study. Information regarding age, gender, body mass index, underlying diseases, smoking habits, medication use, spirometry results, and complete blood count (CBC) was collected and analyzed statistically.<span lang="FA" dir="RTL" style="font-family:"Times New Roman","serif""></span></span></span><br> <span style="font-size:9pt"><span minion="" pro="" style="font-family:"><b>Results</b><b><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times="">: &nbsp;</span></span></b>A total of 103 participants were selected based on the inclusion criteria and participated in the study. In the current study, 8 patients (7.8%) were eosinophilic-positive and 95 patients (92.2%) were eosinophilic-negative. The mean FEV1 in the eosinophilic-negative group was 63.25% (with a standard deviation of 20.585), while in the eosinophilic-positive group it was 60.00% (with a standard deviation of 14.203). Statistical tests confirmed no significant difference between the two groups, suggesting that reduced FEV1 was not associated with blood eosinophilia in this population. Additionally, the mean FEV1/FVC ratio in the eosinophilic-negative group was 80.72% (with a standard deviation of 17.10), and in the eosinophilic-positive group it was 77.33% (with a standard deviation of 15.62), which also showed no statistically significant difference.</span></span><br> <span style="font-size:9pt"><span minion="" pro="" style="font-family:"><b>Conclusion</b><b><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times="">: &nbsp;</span></span></b>This study found no significant association between blood eosinophilia and demographic or pulmonary function variables in patients with obstructive patterns on spirometry. Future studies with more precise designs and larger sample sizes may clarify the role of eosinophilia in prognosis and treatment response.</span></span><br> &nbsp;</p> Pulmonary Disease, Chronic Obstructive, Eosinophilia 40 47 http://jbrms.medilam.ac.ir/browse.php?a_code=A-10-1447-2&slc_lang=en&sid=1 Bahareh Soltani Drbaharehsoltaniinternist@gmail.com 10031947532846008315 0009-0003-0189-5731 No Department of internal medicine, Hazrat Rasoul Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Ayat Ahifar Dr.ahifar@gmail.com 10031947532846008316 0009-0004-0004-9661 Yes Department of internal medicine, Hazrat Rasoul Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Reza Ghaderi rezaghaderi1355@gmail.com 10031947532846008317 10031947532846008317 No Department of internal medicine, Hazrat Rasoul Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Vahan Moradians moradiansva@yahoo.com 10031947532846008318 10031947532846008318 No Department of internal medicine, Hazrat Rasoul Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran