en پژوهشي Research <span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times="">Introduction: </span></b><span new="" roman="" style="font-family:" times="">The anti-inflammatory effects of exercise training and zataria multiflora have been proven. In the present study, researcher investigated the effect of eight weeks combined exercise training and <i>Zataria multiflora (Z. multiflora)</i> supplement on the levels of IL-1&beta; and insulin resistance in overweight and obese men.</span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times="">Materials and Methods: </span></b><span new="" roman="" style="font-family:" times="">The 40 overweight and obese men with average age of 27.73 &plusmn; 2.15 years old and average body mass index (BMI) 28.41 &plusmn; 1.75 kg/m² were randomly divided into four groups including the placebo, <i>Z. multiflora</i>, combined training, and training +</span> <a name="_Hlk121175894"><i><span new="" roman="" style="font-family:" times="">Z. multiflora</span></i></a><span new="" roman="" style="font-family:" times="">. Combined exercise training program conducted for eight weeks and three sessions per week. <i>Z. multiflora</i> supplement was also consumed at 500 mg daily. Blood sampling was performed before and 48 hours after the eight weeks intervention. The levels of IL-1&beta; and insulin were measured by ELISA method. Data were analyzed by analysis of covariance and Bonferroni post hoc test.</span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times="">Results: </span></b><span new="" roman="" style="font-family:" times="">The levels of IL-1&beta; in training and training +</span> <i><span new="" roman="" style="font-family:" times="">Z. multiflora</span></i><span new="" roman="" style="font-family:" times=""> groups significantly decreased compared to placebo and <i>Z. multiflora</i> groups (P < 0.001). In addition, significant decrease of insulin resistance in training group compared to placebo (P < 0.001) and <i>Z. multiflora</i> (P = 0.003) groups, and also in training <i>+ Z. multiflora</i> group compared to placebo <i>and Z. multiflora</i> groups were observed (P < 0.001).</span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times="">Conclusion: </span></b><span new="" roman="" style="font-family:" times="">Combined training alone or in combination with <i>Z. multiflora</i> supplementation can exert anti-inflammatory effects. Moreover, <i>Z. multiflora</i> supplementation cause the relative increase in exercise training effect for decrease in IL-1&beta; and insulin resistance.</span><span style="font-family:"Times New Roman",serif"></span></span></span></span></span><br> &nbsp; Exercise Training, Zataria Multiflora, Inflammation, Cytokine 42 50 http://jbrms.medilam.ac.ir/browse.php?a_code=A-10-459-4&slc_lang=en&sid=1 Alireza Jadid ali.shaghayegh888@yahoo 10031947532846007623 10031947532846007623 No Department of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran Mandana Gholami m.gholami@srbiau.ac.ir 10031947532846007624 10031947532846007624 Yes Department of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran Hossein Abed Natanzi abednazari@gmail.com 10031947532846007625 10031947532846007625 No Department of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran