en Physiology Physiology پژوهشي Research <div style="text-align: justify;"><span style="font-size:9pt"><span minion="" pro="" style="font-family:"><b>Introduction</b>: This study explores the combined effects of concurrent training and capecitabine consumption on breast cancer prevention and therapy, focusing on the modulation of <i>BRCA1</i> gene expression.</span></span><br> <span style="font-size:9pt"><span minion="" pro="" style="font-family:"><b>Material & Methods</b>: In the main study, 12 mice were divided into groups, including Exercise-Tumor-Exercise (ETE), Exercise-Tumor-Exercise+Drug (ETE + D), and various others. Resistance and endurance training were conducted five days a week for 12 weeks before and eight weeks after tumor induction, accompanied by capecitabine administration. <i>BRCA1</i> gene expression was assessed post-intervention using SPSS 20.</span></span><br> <span style="font-size:9pt"><span minion="" pro="" style="font-family:"><b>Results</b>: MC4-L2 injection induced tumors. Both pre and post-cancer induction, exercise significantly increased <i>BRCA1</i> gene expression (p = 0.001, p = 0.001). Exercise combined with post-cancer capecitabine led to increased <i>BRCA1</i> expression (p = 0.001). Capecitabine alone post-cancer also elevated <i>BRCA1</i> expression (p = 0.001). Exercise, exercise with capecitabine, and capecitabine alone post-cancer showed significantly higher <i>BRCA1</i> expression than exercise pre-cancer (p = 0.001). Exercise-tumor-exercise and Exercise-Tumor-Exercise+Drug groups exhibited increased <i>BRCA1</i> expression compared to exercise-tumor-drug (p = 0.001).</span></span><br> <span style="font-size:9pt"><span minion="" pro="" style="font-family:"><b>Conclusion</b><b><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times="">: </span></span></b>The ETE+D protocol, involving exercise and capecitabine post-cancer, increased BRCA1 expression, suggesting potential roles in tumor prevention and therapy.<span lang="FA" dir="RTL" style="font-family:"Times New Roman",serif"></span></span></span></div> Breast cancer, Tumor size, Exercise Therapy, BRCA1, Capecitabine 67 80 http://jbrms.medilam.ac.ir/browse.php?a_code=A-10-718-1&slc_lang=en&sid=1 Masoud Shokuhi Niya masoud_shokuhi73@yahoo.com 10031947532846006917 10031947532846006917 No Department of Sport Sciences, Faculty of Education and Psychology, University of Sistan and Baluchestan, Zahedan, Iran Abbas Salehikia salehikia@ped.usb.ac.ir 10031947532846006918 10031947532846006918 Yes Department of Sport Sciences, Faculty of Education and Psychology, University of Sistan and Baluchestan, Zahedan, Iran Maryam Banparvari banparvari@ped.usb.ac.ir 10031947532846006919 10031947532846006919 No Department of Sport Sciences, Faculty of Education and Psychology, University of Sistan and Baluchestan, Zahedan, Iran Hamed Fanaei 10031947532846006920 10031947532846006920 No Department of Physiology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran