en Physiology Physiology پژوهشي Research <span style="font-size:9pt"><span minion="" pro="" style="font-family:"><b>Introduction</b>: Evidence suggests a link between serum adropin levels and coagulation factors, with physical activity boosting adropin circulation. This study investigates the correlation between adropin and blood coagulation factors in young adults at varying activity levels.</span></span><br> <span style="font-size:9pt"><span minion="" pro="" style="font-family:"><b>Material & Methods</b><b><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times="">: </span></span></b>Fifty healthy young adults were divided into active and inactive groups using the Baecke questionnaire. Blood samples assessed adropin and coagulation factors. Statistical tests included Mann-Whitney and independent t-tests for comparison, with Spearman&#39;s correlation coefficient determining strength.</span></span><br> <span style="font-size:9pt"><span minion="" pro="" style="font-family:"><b>Results</b><b><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times="">: </span></span></b>Active participants exhibited significantly lower fibrinogen (p<0.05) and higher adropin levels (p<0.05) compared to inactive peers. Physical activity correlated negatively (r=-0.27, p=0.05) with fibrinogen but not with adropin and other coagulation factors.</span></span><br> <span style="font-size:9pt"><span minion="" pro="" style="font-family:"><b>Conclusion</b><b><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times="">: &nbsp;</span></span></b>Elevated physical activity levels correlate with heightened serum adropin and reduced serum fibrinogen. Moreover, serum fibrinogen, a critical coagulation factor influencing blood clot formation, appears particularly sensitive to the effects of physical activity.</span></span><br> <span style="font-size:9pt"><span minion="" pro="" style="font-family:"><b><span lang="FA" dir="RTL" style="font-family:"Times New Roman","serif""></span></b></span></span> Adropin, Blood Coagulation Factors, Exercise 70 79 http://jbrms.medilam.ac.ir/browse.php?a_code=A-10-790-1&slc_lang=en&sid=1 Hamid Rajabi hrajabi1346@gmail.com 10031947532846006786 10031947532846006786 Yes Department of Exercise physiology, Faculty of Physical Education and Sport Sciences, Kharazmi University, Tehran, Iran Seyed Sarmad Zahmatkeshan zahmatkeshan.ss@gmail.com 10031947532846006787 10031947532846006787 No Department of Exercise physiology, Faculty of Physical Education and Sport Sciences, Kharazmi University, Tehran, Iran Azam Ahmadi ahmadi.azam@gmail.com 10031947532846006788 10031947532846006788 No Department of Exercise physiology, Faculty of Physical Education and Sport Sciences, Kharazmi University, Tehran, Iran