en Medical physics Medical physics مقالات مروری Narrative review <span style="font-size:9pt"><span minion="" pro="" style="font-family:"><b>Introduction</b>: Despite advances in cancer therapy, many treatments result in significant side effects and inconsistent remission. This review was aimed at exploring the potential of Auger electrons (AEs) as a novel, highly localized approach to cancer treatment.</span></span><br> <span style="font-size:9pt"><span minion="" pro="" style="font-family:"><b>Materials & Methods</b><b><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times="">: </span></span></b>Relevant studies were reviewed to examine the mechanism of action of AEs emitted from radioisotopes, their DNA-damaging effects, and their selective activity in cancer cells. The analysis also included recent developments in cancer cell detection based on surface charges, radionuclide delivery systems, and the role of proton tunneling and low-energy electrons in DNA disruption.<span lang="FA" dir="RTL" style="font-family:"Times New Roman","serif""></span></span></span><br> <span style="font-size:9pt"><span minion="" pro="" style="font-family:"><b>Results</b><b><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times="">: &nbsp;</span></span></b>Auger electrons, characterized by low energy and high linear energy transfer (LET), induce lethal DNA damage with minimal impact on surrounding healthy tissue. They act through direct DNA interaction or indirectly via water ionization. Detection methods based on cell surface charge properties showed promise in improving cancer cell targeting. Additionally, advancements in radionuclide carriers enhanced delivery precision. Insights into proton tunneling supported the biological relevance of low-energy electrons in therapeutic applications.</span></span><br> <span style="font-size:9pt"><span minion="" pro="" style="font-family:"><b>Conclusion</b><b><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times="">: &nbsp;</span></span></b>Auger electron therapy offers a promising, targeted strategy for cancer treatment with reduced collateral damage. Continued research is needed to refine delivery systems and better understand electron-cell interactions to maximize therapeutic outcomes.</span></span><br> &nbsp; Radioisotopes, DNA Damage, Neoplasms 17 29 http://jbrms.medilam.ac.ir/browse.php?a_code=A-10-889-1&slc_lang=en&sid=1 Mohsen Emami-Razavi razavi246@gmail.com 10031947532846008282 10031947532846008282 No Department of Physics, College of Converging Sciences and Technologies, Science and Research Branch, Islamic Azad University, Sarina Abbasi Dezfouli sarinaabbasidezfouli@gmail.com 10031947532846008283 0009-0002-3699-7589 Yes Department of Physics, College of Converging Sciences and Technologies, Science and Research Branch, Islamic Azad University, Tehran, Iran