[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
About Journal::
Editorial Board::
Articles Archive::
Indexing Databases::
To Authors::
To Reviewers::
Registration::
Submit Your Article::
Policies and Publication Ethics::
Archiving Policy::
Site Facilities::
Contact Us::
::
Google Scholar Metrics

Citation Indices from GS

AllSince 2019
Citations709570
h-index1110
i10-index1512
..
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
Registered in

AWT IMAGE

AWT IMAGE

..
:: Volume 8, Issue 3 (6-2021) ::
2021, 8(3): 32-39 Back to browse issues page
The effect of aerobic exercise combined with bone marrow mesenchymal stem cells on inflammatory biomarkers levels of the brain in a model of osteoarthritic rat
Mohamad Fatahi , Naser Behpoor , Sedighe Hosseinpourdelavar , Parvin Farzaneghi
Department of Exercise Physiology, Razi University, Kermanshah, Iran , n_behpoor@yahoo.com
Abstract:   (1523 Views)
Introduction: Osteoarthritis is a degenerative disease that has many public health problems. Interleukin 10 (IL-10) and tumor necrosis factor alfa (TNF-α) are considered as the main factors regulating inflammation and pathology of knee osteoarthritis. This study was done to investigate the effects of mesenchymal stem cells (MSCs) and aerobic training on inflammatory biomarkers (IL-10 and TNF- α) in the brain tissue of osteoarthritic rats.
Materials and Methods: In this experimental study, 48 male Wistar rats were randomly divided into six groups (n=8 in each group) as follows: 1. Naive (healthy control), 2. Osteoarthritis (Ost), 3. Osteoarthritis + saline (Sal), 4. Osteoarthritis + mesenchymal cells (Mes), 5. Osteoarthritis + training (Tra), and 6. Osteoarthritis + training + mesenchymal cells (Tra + Mes). An essential aerobic exercise program was performed for eight weeks as follows:  Speed: 15-22 meters per minute; Slope: 0o for 25-64 minutes. Inflammatory biomarkers, including TNF-α and IL-10 cytokines, in the brain tissue of rats, were measured using enzyme-linked immunosorbent assay.
Results: The combination of training and treatment with MSCs in the brain of osteoarthritic rats significantly increased the level of IL-10 in comparison with the use of MSCs or aerobic exercise alone. Moreover, the combined use of exercise and MSCs caused a significant decrease in TNF-α concentration.
Conclusion: It seems that the combined use of MSCs and eight weeks of aerobic exercise improves the concentration of inflammatory biomarkers in the brain of a rat model of osteoarthritis.
Keywords: Exercise, Osteoarthritis, Inflammation, Stem cells
Full-Text [PDF 246 kb]   (566 Downloads)    
Type of Study: Research | Subject: Physiology
Received: 2020/05/20 | Accepted: 2020/07/16 | Published: 2021/06/30
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Fatahi M, Behpoor N, Hosseinpourdelavar S, Farzaneghi P. The effect of aerobic exercise combined with bone marrow mesenchymal stem cells on inflammatory biomarkers levels of the brain in a model of osteoarthritic rat. Journal of Basic Research in Medical Sciences 2021; 8 (3) :32-39
URL: http://jbrms.medilam.ac.ir/article-1-520-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 8, Issue 3 (6-2021) Back to browse issues page
مجله ی تحقیقات پایه در علوم پزشکی Journal of Basic Research in Medical Sciences
Persian site map - English site map - Created in 0.16 seconds with 41 queries by YEKTAWEB 4643