Correlating Serum Adropin Levels with Blood Coagulation Indices across Physical Activity Levels in Young Adults

Rajabi , Hamid; Zahmatkeshan , Seyed Sarmad; Ahmadi , Azam

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Volume 11, Issue 2 (4-2024)

2024, 11(2): 70-79

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Correlating Serum Adropin Levels with Blood Coagulation Indices across Physical Activity Levels in Young Adults

Hamid Rajabi

, Seyed Sarmad Zahmatkeshan

, Azam Ahmadi

Department of Exercise physiology, Faculty of Physical Education and Sport Sciences, Kharazmi University, Tehran, Iran , hrajabi1346@gmail.com

Abstract: (319 Views)

Introduction: Evidence suggests a link between serum adropin levels and coagulation factors, with physical activity boosting adropin circulation. This study investigates the correlation between adropin and blood coagulation factors in young adults at varying activity levels.
Material & Methods: Fifty healthy young adults were divided into active and inactive groups using the Baecke questionnaire. Blood samples assessed adropin and coagulation factors. Statistical tests included Mann-Whitney and independent t-tests for comparison, with Spearman's correlation coefficient determining strength.
Results: Active participants exhibited significantly lower fibrinogen (p<0.05) and higher adropin levels (p<0.05) compared to inactive peers. Physical activity correlated negatively (r=-0.27, p=0.05) with fibrinogen but not with adropin and other coagulation factors.
Conclusion: Elevated physical activity levels correlate with heightened serum adropin and reduced serum fibrinogen. Moreover, serum fibrinogen, a critical coagulation factor influencing blood clot formation, appears particularly sensitive to the effects of physical activity.

Keywords: Adropin, Blood Coagulation Factors, Exercise

Full-Text [PDF 1577 kb] (39 Downloads)

Type of Study: Research | Subject: Physiology
Received: 2024/01/11 | Accepted: 2024/04/22 | Published: 2024/04/22

References

1. Gao S, Ghoshal S, Zhang L, Stevens JR, McCommis KS, Finck BN, et al. The peptide hormone adropin regulates signal transduction pathways controlling hepatic glucose metabolism in a mouse model of diet-induced obesity. J Biol Chem. 2019;294(36):13366-77. doi: 10.1074/jbc.RA119.008967

2. Zhang C, Zhao L, Xu W, Li J, Wang B, Gu X, et al. Correlation of serum adropin level with coronary artery disease. Zhonghua Yi Xue Za Zhi. 2014;94(16):1255-7.

3. Shamizadeh M, Zolfaghari MR, Fattahi A. Effect of eight weeks of aerobic and resistance training on adropin, spexin, and TNFα levels, as well as insulin resistance indices, in obese men with type 2 diabetes. JIUMS. 2023;31(5):70-84.

4. Celik A, Balin M, Kobat MA, Erdem K, Baydas A, Bulut M, et al. Deficiency of a new protein associated with cardiac syndrome X; called adropin. Cardiovasc Ther. 2013;31(3):174-8. doi: 10.1111/1755-5922.12025

5. Zhao LP, Xu WT, Wang L, You T, Chan SP, Zhao X, et al. Serum adropin level in patients with stable coronary artery disease. Heart Lung Circ. 2015;24(10):975-9. doi: 10.1016/j.hlc.2015.03.008.

6. Fujie S, Hasegawa N, Kurihara T, Sanada K, Hamaoka T, Iemitsu M. Association between aerobic exercise training effects of serum adropin level, arterial stiffness, and adiposity in obese elderly adults. Appl Physiol Nutr Metab. 2017;42(1):8-14. doi: 10.1139/apnm-2016-0310

7. Lovren F, Pan Y, Quan A, Singh KK, Shukla PC, Gupta M, et al. Adropin is a novel regulator of endothelial function. Circulation. 2010;122(11_suppl_1):S185-S92. doi: 10.1161/CIRCULATIONAHA.109.931782.

8. Zhang S, Chen Q, Lin X, Chen M, Liu Q. A review of adropin as the medium of dialogue between energy regulation and immune regulation. Oxid Med Cell Longev. 2020;2020: 1-7. doi.org/10.1155/2020/3947806.

9. Zhang H, Chen N. Adropin as an indicator of T2DM and its complications. Food Sci Hum Wellness. 2022;11(6):1455-63. Doi: org/10.1016/j.fshw.2022.06.002

10. Soltani S, Beigrezaei S, Malekahmadi M, Clark CC, Abdollahi S. Circulating levels of adropin and diabetes: a systematic review and meta-analysis of observational studies. BMC Endocr Disord. 2023;23(1):1-11. doi: 10.1186/s12902-023-01327-0.

11. Marczuk N, Cecerska-Heryć E, Jesionowska A, Dołęgowska B. Adropin–physiological and pathophysiological role. Postepy Hig Med Dosw. 2016;70:981-8. doi: 10.5604/17322693.1220082.

12. Aggarwal G, Morley JE, Vellas B, Nguyen AD, Butler AA. Low circulating adropin concentrations predict increased risk of cognitive decline in community-dwelling older adults. Geroscience. 2024;46(1):897-911. doi: 10.1007/s11357-023-00824-3.

13. Fujie S, Hasegawa N, Sato K, Fujita S, Sanada K, Hamaoka T, et al. Aerobic exercise training-induced changes in serum adropin level are associated with reduced arterial stiffness in middle-aged and older adults. Am J Physiol Heart Circ Physiol. 2015;309(10):H1642-H7. doi: 10.1152/ajpheart.00338.2015.

14. Randriamboavonjy V, Fleming I. Endothelial nitric oxide synthase (eNOS) in platelets: how is it regulated and what is it doing there? Pharmacol Rep. 2005;57:59.56-65.

15. Park J, Piknova B, Nghiem K, Lozier J, Schechter A. Inhibitory effect of nitrite on coagulation processes demonstrated by thrombelastography. Nitric Oxide. 2014;40:45-51. doi: 10.1016/j.niox.2014.05.006

16. Bochenek ML, Schäfer K. Role of endothelial cells in acute and chronic thrombosis. Hamostaseologie. 2019;39(02):128-39. doi: 10.1055/s-0038-1675614

17. Goldstein B, Baldassarre J, Young JN. Effects of inhaled nitric oxide on hemostasis in healthy adults treated with heparin: a randomized, controlled, blinded crossover study. Thromb J. 2012;10(1):1-10.

18. Sadeghi Hashjin G, Asghari M. The Effects of Nitric Oxide on Blood Coagulation Process. JABS. 2019;9(4):1703-9.

19. Sadeghisani M, Manshadi FD, Azimi H, Montazeri A. Validity and reliability of the Persian version of Baecke habitual physical activity questionnaire in healthy subjects. Asian J Sports Med. 2016;7(3). e31778. Doi: org/10.5812/asjsm.31778.

20. Lee KW, Lip GY. Effects of lifestyle on hemostasis, fibrinolysis, and platelet reactivity: a systematic review. Arch Intern Med. 2003;163(19):2368-92. doi: org/10.1001/archinte.163.19.2368.

21. Olsen LN, Fischer M, Evans PA, Gliemann L, Hellsten Y. Does exercise influence the susceptibility to arterial thrombosis? An integrative perspective. Front Physiol. 2021;12:636027. doi: 10.3389/fphys.2021.636027.

22. El-Sayed MS. Effects of exercise on blood coagulation, fibrinolysis and platelet aggregation. Sports Med. 1996;22:282-98. doi: 10.2165/00007256-199622050-00002.

23. Amini A, Kordi MR, Gaini AA, Ahmadi A, Ayoubian H, Lahoorpour F. The effects of aerobic exercises on coagulation and fibrinolytic factors in inactive aged men. SJKU. 2011;15(4):25-32.

24. Zanettini R, Bettega D, Agostoni O, Ballestra B, del Rosso G, Di Michele R, et all. Exercise training in mild hypertension: effects on blood pressure, left ventricular mass and coagulation factor VII and fibrinogen. Cardiology. 1997;88(5):468-73. doi: 10.1159/000177378.

25. Furukawa F, Kazuma K, Kojima M, Kusukawa R. Effects of an off-site walking program on fibrinogen and exercise energy expenditure in women. Asian Nurs Res. 2008;2(1):35-45. doi: 10.1016/S1976-1317(08)60027-4.

26. Van den Burg P, Hospers J, Van Vliet M, Mosterd W, Bouma B, Huisveld I. Changes in haemostatic factors and activation products after exercise in healthy subjects with different ages. Thromb Haemost. 1995;74(12):1457-64.

27. Lippi G, Salvagno GL, Montagana M, Guidi GC. Chronic influence of vigorous aerobic training on hemostasis. Blood coagul fibrinolysis. 2005;16(7):533-4. doi: 10.1097/01.mbc.0000183117.66605.a3.

28. Mahdirajei A, Mirsaiedii M, Fadaei Reihan Abadei S. Compare the Effect of 4 Weeks of Resistance and Aerobic Training on Blood Coagulation and Fibrinolytic Factors in Inactive Older Men. MUMS. 2013;56(3):150-8. doi: org/10.22038/mjms.2013.1226.

29. Parlak H, Ozkan A, Sinen O, Bulbul M, Aslan MA, Agar A. Adropin increases with swimming exercise and exerts a protective effect on the brain of aged rats. Exp Gerontol. 2022;169:111972. doi: 10.1016/j.exger.2022.111972. Epub 2022 Oct 7.

30. Baecke JA, Burema J, Frijters JE. A short questionnaire for the measurement of habitual physical activity in epidemiological studies. Am J Clin Nutr. 1982;36(5):936-42. doi: 10.1093/ajcn/36.5.936.

31. Burg PVD, Hospers J, Van Vliet M, Mosterd W, Bouma B, Huisveld I. Effect of endurance training and seasonal fluctuation on coagulation and fibrinolysis in young sedentary men. J Appl Physiol. 1997;82(2):613-20. doi: 10.1152/jappl.1997.82.2.613

32. Rezaiean Z, Torkaman G, Nadali F. Effect of physical fitness on the coagulate activity of healthy young men. Pak J Biol Sci. 2006;9(11):2032-9. doi: 10.3923/pjbs.2006.2032.2039.

33. 33. Fathei M, Mir E. The effect of 12 resistance training sessions on some coagulation and fibrinolytic factors in non-active men. JPSBS. 2015;3(5):56-66. doi: org/10.22077/jpsbs.2015.15.

34. Hörber S, Lehmann R, Fritsche L, Machann J, Birkenfeld AL, Häring H-U, et al. Lifestyle intervention improves prothrombotic coagulation profile in individuals at high risk for type 2 diabetes. The J Clin Endocrinol Metab. 2021;106(8):e3198-e207. doi: 10.1210/clinem/dgab124.

35. Indolfi C, Torella D, Coppola C, Curcio A, Rodriguez F, Bilancio A, et al. Physical training increases eNOS vascular expression and activity and reduces restenosis after balloon angioplasty or arterial stenting in rats. Circ Res. 2002;91(12):1190-7.doi: org/10.1161/01.RES.0000046233.94299.D6.

36. Eliasson M, Asplund K, Evrin PE. Regular leisure time physical activity predicts high activity of tissue plasminogen activator: The Northern Sweden MONICA Study. Int J Epidemiol . 1996;25(6):1182-8. doi: 10.1093/ije/25.6.1182.

37. Hilberg T, Eichler E, Gläser D, Prasa D, Stürzebecher J, Gabriel HH. Blood coagulation and fibrinolysis before and after exhaustive exercise in patients with IDDM. Thromb Haemost. 2003;90(12):1065-73. doi: 10.1160/TH03-05-0264.

38. Menzel K, Hilberg T. Coagulation and fibrinolysis are in balance after moderate exercise in middle-aged participants. Clin Appl Thromb Hemost . 2009;15(3):348-55. doi: 10.1177/1076029608326306.

39. Zhang H, Jiang L, Yang YJ, Ge RK, Zhou M, Hu H, et al. Aerobic exercise improves endothelial function and serum adropin levels in obese adolescents independent of body weight loss. Sci Rep. 2017;7(1):17717. doi: 10.1038/s41598-017-18086-3.

40. Shrabyany S, Rajabi H, Motamedi P, Dehkhada M, Kaviani M. The Effect of Eight Weeks of Combined Exercise on Serum Adipine and Nitric Oxide Levels in High Pressure Menopausal Women. J Physiol Manag Res Sport Round. 2019;11(1):129-43.

41. Gomez-Marcos MA, Recio-Rodríguez JI, Patino-Alonso MC, Martinez-Vizcaino V, Martin-Borras C, de-la-Cal-Dela-Fuente A, et al. Relationship between physical activity and plasma fibrinogen concentrations in adults without chronic diseases. PLoS One. 2014;9(2):e87954. doi: org/10.1371/journal.pone.0087954.

42. Koenig W, Ernst E. Exercise and thrombosis. Coron Artery Dis. 2000;11(2):123-7. doi: 10.1097/00019501-200003000-00006.

43. Vanninen E, Laitinen J, Uusitupa M. Physical activity and fibrinogen concentration in newly diagnosed NIDDM. Diabetes care. 1994;17(9):1031-8. doi: 10.2337/diacare.17.9.1031.

44. Ponjee G, Janssen G, Van Wersch J. Prolonged endurance exercise and blood coagulation: a 9 month prospective study. Blood Coagul Fibrinolysis. 1993;4(1):21-5.

45. Bodary PF, Yasuda N, Watson DD, Brown AS, Davis JM, Pate RR. Effects of short-term exercise training on plasminogen activator inhibitor (PAI-1). Med Sci Sports Exerc. 2003;35(11):1853-8. doi: 10.1249/01.MSS.0000093751.82616.F0.

46. Ahmadizad S, El-Sayed MS, MacLaren DP. Effects of water intake on the responses of haemorheological variables to resistance exercise. Clin Hemorheol Microcirc. 2006;35(1-2):317-27.

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Rajabi H, Zahmatkeshan S S, Ahmadi A. Correlating Serum Adropin Levels with Blood Coagulation Indices across Physical Activity Levels in Young Adults. Journal of Basic Research in Medical Sciences 2024; 11 (2) :70-79
URL: http://jbrms.medilam.ac.ir/article-1-810-en.html

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