Introduction: Congenital anomalies are a common cause of disability and mortality in newborns and their treatments involves high costs for the society. This study aimed to investigate the prevalence of congenital anomalies and their causes.

Materials and methods: This research was a descriptive-analytical study and the population included all the newborns in hospitals of the city of Ilam in 2011. Variables of abnormality type, birth status, and medical and genetic illness histories were included into the data collection forms. Data was analyzed through Chi-square tests and Fisher's exact test using SPSS software.

Results: Of 460 neonates, 5.4 percent (25 cases) had died at birth and 3.7 percent (16 infants) were born with a birth defect. 43.8 percent of malformed babies had a family history. 31.3 % of the malformed babies had genetic syndromes, whose parents had consanguineous marriage. 18.8% of babies with defects in the central nervous system and cardiovascular system showed a similar percentage of disorder. The defect in the urinary system, head and neck each accounted for 12.5 percent.

Conclusion: This study shows that consanguineous marriages can be the most common genetic cause of genetic syndromes.

A 28 years’ pregnant woman with 24 weeks’ gestational age referred with petechiae and purpura from previous day without any trauma. She had an occipital headache from last night. Overt petechial and purpuric lesions were seen in the mouth and skin. There was neither hepatosplenomegaly nor lymphadenopathy. She was conscious and oriented. The patient was febrile, anemic and thrombocytopenic with stable vital signs. All liver enzymes were elevated. Coagulation profile was normal. WBCs were normal. RBCs were reduced, and she had polychromatosis. Overt shistocytosis was seen. Platelets were significantly decreased. The first diagnosis was TTP. All necessary laboratory tests were done to rule out the secondary rheumatologic causes of TTP; which all were normal. Coombs tests were negative. ADAMTS 13 Ab was elevated. Fetal ultrasonography was normal.

Treatment started with plasmapheresis and corticosteroid. After treatment, platelets count begins elevated, and LDH decreased. The patient discharged with a good general condition and normal lab tests. She continued her pregnancy until term, and born a normal infant without any complication. She did not have a recurrence of TTP until September 2014.

Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults. Anemia is world health problems and common medical conditions seen in clinical practice. We report the case of a 47-years-old woman who presented pain and obvious changes in hallux. With regard to available symptoms, special issues like strike, CLL, banned veins of foot and occult blood was guessed as a general mechanism of disease. But the result of performed tests and the effect of used drugs exclude all mentioned problems and low hemoglobin level was recognized as the only crucial cause of disease. With according to the results of blood counts and symptoms, disease for CLL, after performing tests and treatment of disease with iron supplementation, we recognized that particularly iron deficiency is the essential cause of disease.

Dear Editor,
 
Shortly after the first outbreak in China, the Corona virus has affected many countries around the world. The first confirmed case of the virus in Iran was reported in Qom on February 2020, and then it spread to other cities in Iran. The outbreak has caused many social and economic challenges for the international community; also, there is no complete information about this disease.
One of the most important challenges is the prevalence of inaccurate information about the disease, which has many psychological, political, social and economic effects on society. Infodemic or the spread of wrong information about the disease through various social media in the global community is a serious problem for public health.
The dissemination of information can severely affect people's behavior and alter the effectiveness of governments’ countermeasures. In this present letter was reviewed integrated portal as a one of the solutions to infodemic management. The use of authentic sources to provide accurate information in the community is one of the best approaches to combat this phenomenon. Timely information sharing and comparison of epidemiological and genomic data on infectious diseases leads to faster and more efficient control of global outbreaks and disease tracking. In spite of all the problems in this area, various solutions have been proposed for this issue.
The portal is one of the significant technologies which provide correct and required data for different users. Web portals are increasingly becoming part of modern life. Portals collect uniform information from multiple sources and provide consistent access to multiple information, software and applications from different databases to organizations and community. Portal content is available from a variety of tools such as PCs and smartphones. For example, government web-portals can be used by public and private organizations. Many studies have confirmed the usefulness of portals for managing infectious and chronic diseases, if it is designed according users need.
The accurate and comprehensive information sharing with all stakeholders and health organizations such as WHO about Covid-19 is essential for better management of the disease.
One of the applications of portals is sharing of accurate and reliable information by responsible authorities for managing this disease. Justice must be respected in presenting results of recent research on Covid 19, and everyone has equal access to this information according to their role in society. By sharing the results of scientific research, the general public are also preparing themselves to fight the disease.
In recent days, various applications, soft wares and websites have been provided by the relevant organizations for the effective management of CVD 19. The integration of these technologies into comprehensive portal is essential for a comprehensive management of disease.
The portal will be accessible to public, patients, providers and policy makers. It can prepare educational, medical, and research information for users.
Some benefits of portal including information gathering from various sources, availability of information for all user groups (general and specific users), uploading information by users according to the access level, designing customized pages by users or groups, decreasing the attendance of patients and public in high risk areas, increasing information security, reducing people's confusion about finding the required information and facilitating communication.

Aluminum phosphide (ALP) is a very toxic compound commercially accessible as "rice tablet" in some markets in Iran. Although this toxin is used as a pesticide to protect grains from pests, it may be used for committing suicide. The poisoned patient experiences gastrointestinal problems as the first clinical manifestations in case of oral use, then develops acid-base disturbance, shock, and death in many cases. Intoxication with ALP can also affect the patient's hemodynamic status and cause electrocardiograph alterations, dysrhythmias, and even myocardial necrosis. In the current study, we introduce a young man who consumed an ALP tablet in a suicidal attempt and developed myocardial infarction even before metabolic acidosis and hypotension.

Introduction: Body defects impact well-being, necessitating efficient prosthetic techniques. This report explores integrating CAD/CAM technology for auricular prostheses, emphasizing a digital approach.
MaterialS & Methods: The plan involved irreversible hydrocolloid impressions, generating a digital resin model through an indirect scanner. Traditional molding and 3D printing combined for pattern formation. The mold's investment, fabrication, and coloring used intrinsic and extrinsic painting.
Results: CAD/CAM showcased enhanced compatibility and aesthetics. The digital resin model improved adaptability, streamlining production, and accelerating the wax try-in process. Patient satisfaction during follow-ups validated the prosthesis success.
Conclusion: Exploring auricular prosthesis advancements via digital technology, particularly the digital resin model, demonstrated transformative outcomes. This approach not only enhances adaptability and aesthetics but also expedites production, promising a seamless and time-efficient restoration of ear aesthetics for individuals.