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Showing 2 results for Cheragh-Birjandi
Sadegh Cheragh-Birjandi, Maryam Baghernejad, Farideh Haghighi, Reza Ganji, Hasan Saadati, Mohammadreza Jafari,
Volume 9, Issue 3 (6-2022)
Abstract
Introduction: This study aimed to investigate the effect of resistance training and nano-curcumin supplementation on matrix metallopeptidase 13 (MMP13) and cartilage oligomeric matrix protein (COMP) in patients with knee osteoarthritis.
Materials and Methods: In this open-label parallel randomized trial study 40 women aged between 45-60 years with knee osteoarthritis (OA) were randomly divided into the control, resistance training, nano-curcumin supplementation, and resistance training + nano curcumin supplementation groups. Socio-demographic characteristics, anthropometric and clinical parameters of the patients (WOMAC test) were collected at the beginning and end of the study. The levels of MMP 13 and COMP in the synovial fluid were measured with a human-specific ELISA kit.
Results: Resistance training, supplement intake, and training/supplementation did not significantly change the synovial levels of COMP and MMP 13. Compared with the control group, WOMAC scores were significantly higher in the intervention groups (P = 0.038).
Conclusion: Resistance training and nano-curcumin by changing the WOMAC scores of patients with osteoarthritis can have a beneficial effect on improving the condition of these patients.
Zahra Toktam-Barmar, Sadegh Cheragh-Birjandi, Najmeh Rezaeian,
Volume 9, Issue 4 (9-2022)
Abstract
Introduction: Tissue dysfunction might be the result of reactions between free radicals and cell membranes. The purpose of this study was the evaluation of cell vulnerability and assessment of the effect of intense intermittent exercise and curcumin supplementation on apoptotic and antiapoptotic factors in Wistar rats.
Materials and Methods: For the study, 60 adult male Wistar rats were randomly divided to 5 groups (n = 8) of saline, hydrogen peroxide (H2O2), high intensity interval training (HIIT) + oxygenated Water, Curcumin Supplement + Oxygenated Water, and HIIT + Curcumin Supplement + Oxygenated Water. Rats were treated with H2O2 in the amount of 1 mmol/kg of body weight three times a week on even days and curcumin, 150 m
g/kg of body weight, daily. Treadmill running program was performed for 8 weeks. Real-time PCR was applied to assess Bcl-2-associated X protein (Bax) and B-cell lymphoma 2 (Bcl-2) genes expression. Data were analyzed by using the Two-way ANOVA.
Results: The induction of oxidative stress by H2O2 increased expression of Bax, and decreased expression of Bcl-2 in hippocampus of rats (P = 0.0001). HIIT and curcumin supplementation decreased expression of Bax, and increased expression of Bcl-2, Also, decreased the Bax/Bcl-2 ratio (P = 0.0001).
Conclusion: This finding showed that doing HIIT and taking curcumin supplements have been able to decreas oxidative stress, and the effect of both together could further reduce the apoptotic process.
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