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Showing 3 results for Insulin Resistance
Enaiat Anvari, Sara Keshtgar , Ali Noorafshan, Ali Rafati,
Volume 1, Issue 4 (12-2014)
Abstract
Introduction: High calorie diet is becoming the most important health problem in most developed western societies. Diets with high caloric contents such as high fructose intake are associated with increasing risk of type two diabetes (T2D) and insulin resistance (IR). However, large differences have been seen in the dose and duration of fructose consumption to induction of T2D. Interest to develop animal models, in which IR is induced by feeding a high caloric diet, is the main aim of this study. Materials and methods: Male Sprague-Dawley rats were randomly sorted into three groups, control and fructose-treated (10 and 20 %) animals. After 6 and 14 weeks, fluid intake, body weight, intraperitoneal glucose tolerance test, metabolic parameters (glucose, insulin, triglyceride, cholesterol, uric acid) and homeostasis model assessment of insulin resistance were checked. Results: There was no difference between the body weight of the fructose-treated (10 and 20 %) and control groups during the experiment. Fluid intake in fructose-treated ones (10 and 20 %) was significantly higher than the control group from third week to the end of experiment. Intraperitoneal glucose tolerance test was the same for all groups in either sixth or fourteenth weeks. Fasting plasma insulin, triglyceride, uric acid and homeostasis model assessment of insulin resistance and glucose tests showed significant enhancement in fructose-treated rats (20%) only after 14 weeks. Conclusion: Consumption of high fructose solution (20%) for 14 weeks could induce IR, but using of low dose of fructose (10% for 6 or 14 weeks) didn’t develop it.
Azadeh Yaghoubian, Maghsoud Peeri, Mohammad Ali Azarbayjani,
Volume 9, Issue 1 (1-2022)
Abstract
Introduction: Obesity related inflammation plays an important role in the pathogenesis of insulin resistance and type 2 diabetes. In contrast, exercise training can decrease insulin resistance by modulating inflammation. The aim of present study was to investigate the effect of 12 weeks different intensity circuit resistance training on the levels of the inflammatory mediators, IL-6 and TNF-α in obese postmenopausal women.
Materials and Methods: In the study, 44 postmenopausal women with average age of 56.07 ± 3.18 years old were selected and randomly assigned in four group including the control, low (L-RT), moderate (M-RT) and high intensity circuit resistance training (H-RT) groups. Circuit resistance training for L-RT, M-RT and H-RT groups, respectively, was conducted with 40, 60 and 80 percent of one repetition maximum. Blood sampling prepared in the pre and post-test stages and the plasma levels of TNF-α and IL-6 were measured by an immunoassay method.
Results: There was no significant difference between the groups under study for TNF-α levels (P = 0.097), but inter group difference indicated that a significant decrease in the level of TNF-α in H-RT group (P = 0.004). The IL-6 levels showed a significant between-groups difference (P = 0.013) and also a significant decrease in the levels of IL-6 in H-RT group compared to L-RT group were observed (P = 0.049). Moreover, inter group analysis indicated significant decrease in the level of IL-6 only in H-RT group (P = 0.002).
Conclusion: It seems that, the highest intensity circuit resistance training is more effective in downregulation of inflammatory mediators, and, in turn, the modulation of inflammation is associated with the decreased insulin resistance.
Mitra Sobhanipoor, Reza Nouri, Abbasali Gaeini,
Volume 9, Issue 3 (6-2022)
Abstract
Introduction: This study aimed to evaluate the effect of 12 weeks of interval resistance training with different intensities (low, medium and high) on bone morphogenetic protein 2 (BMP-2), bone morphogenetic protein 4 (BMP-4) and insulin resistance in obese men.
Materials and Methods: Forty-four obese not trained men, after determining 1RM and based on anthropometric characteristics were divided into the control, low-intensity interval resistance training, medium-intensity interval resistance training, high-intensity interval resistance training groups (in each group, n=11). The protocol of interval resistance training includes 8 movements which were periodic and in different intensities in the form of 3 Set 10 repetitions with 80% 1 RM, rest between sets active, and with 20% intensity and the number of repetitions 15 in the high-intensity group, in the medium intensity group in the form of 3 sets 13 repetitions with 60% RM, resting active sets with 20% intensity and number 15 repetitions and in the low-intensity group in the form of 3 sets of 20 repetitions with 40% 1 RM, rest between sets was active with 20% intensity and the number of repetitions was 15. The first fasting blood sample was obtained 48 hours before and the second blood sample was collected 48 hours after a twelve-week training period. Then the measurements were performed.
Results: The 12 weeks of interval resistance training with different intensities in the training groups led to a significant decrease in BMP-2 and insulin resistance compared to the control group (P < 0.001) but for BMP-4 these decreases were not significant (P = 0.055).
Conclusion: The study showed that different intensities of resistance interval training, especially moderate and high intensity training, can decrease the BMP-2, BMP-4 levels and improve insulin resistance.
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