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Showing 2 results for Malondialdehyde
Najmeh Arabnejad, Farshad Ghazalian, Hamid Najafipour, Hossein Abed Natanzi,
Volume 9, Issue 4 (9-2022)
Abstract
Introduction: Malondialdehyde (MDA) is known as an important biomarker for assessing oxidative stress, which exert many pathological effects. The present study sought to investigate the effect of endurance training on the serum and cardiac levels of malondialdehyde (MDA) and lipid profile in the high fat fed male rats.
Materials and Methods: For the 21 male Wistar rats (weighing 200-250g) randomly assigned in three equal groups including the control (C; received normal diet), 60% high-fat diet (HF), and 60% HF + endurance training group (HFE). The HF and HFE groups received 60% calories from fat for 12 weeks. Subsequently, endurance training program performed for six weeks (5 session per week) by the HFE group. Following completing intervention, blood and heart tissue samples collected, and the MDA and lipid profile were measured. Data were analyzed by SPSS-24 software, using one-way ANOVA test.
Results: Serum MDA in the C and HFE groups was significantly lowered compared to the HF group (P < 0.05). Cardiac MDA also represented a significant decrease in the C and HFE groups compared to the HF group (P < 0.05). Moreover, endurance training result in significant improvement in the lipid profile compared to the HF group (P < 0.05).
Conclusion: It seems that exercise training can be considered as an effective strategy for ameliorate the pathological effect of high fat feeding, partly exerted by downregulation of serum and cardiac MDA levels and the lipid profile improvement.
Sajjad Salari , Maryam Bagheri ,
Volume 11, Issue 4 (9-2024)
Abstract
Introduction: Propylene glycol (PG) is frequently used as a solvent for various medications. However, there is substantial evidence of Propylene glycol toxicity, such as depression, agitation, and seizures, particularly when used in combination with other drugs. Here, we aimed to study the effect of Propylene glycol administration in combination with amyloid β₁₋₄₀ injection on hippocampal neurons.
Material & Methods: Thirty-six male Wistar rats were randomly divided into four groups: sham, amyloid β₁₋₄₀ injection group, Propylene glycol group, and amyloid β₁₋₄₀ + Propylene glycol group. Alternation behavior, number of neurons in the hippocampus, lipid peroxidation markers, and superoxide dismutase levels were analyzed in all rats.
Results: When Propylene glycol was co-administered with amyloid β₁₋₄₀, a notable reduction in the mean neuronal count was observed in the CA1, CA3, and DG regions compared with the amyloid β₁₋₄₀ only injected animals (P < 0.05). Furthermore, Propylene glycol induced an increase in lipid peroxidation markers (10.78 ± 0.4) and a decrease in antioxidant content (2.8 ± 0.17) when administered with amyloid β₁₋₄₀, compared to the animals that received only amyloid β₁₋₄₀ (P < 0.05). A similar pattern was found in alternation behavior compared with the group with amyloid β₁₋₄₀ injection (P < 0.001).
Conclusion: Propylene glycol could produce excessive neurotoxicity in regions of the hippocampus when co-administered with amyloid β₁₋₄₀. It likely increases lipid peroxidation and reduces superoxide dismutase in the rat brain. The use of different agents as a vehicle should be considered, especially in the elderly.
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