Introduction: Telomeres are repetitive sequences of TTAGGG section that find at two ends of eukaryotic chromosomes and they shield chromosome ends. Telomere shortening in patients with myocardial infarction has been reported. Shelterin complex's role is essential in telomere length regulation. Telomeric repeat binding factors 1 and 2 (TRF1 and TRF2) are the most important sheltrein complex proteins. The purpose of this study was to investigate the effect of eight weeks of rehabilitation training on TRF1 and TRF2 in myocardial infarction patients.

Materials and methods: In this Quasi-experimental pre-post intervention study, twenty male patients selected and randomly assigned to training (n=10) or control (n=10) groups. Rehabilitation training was eight weeks of concurrent training, 3 time per week. For TRF1 and TRF2 assessment, blood samples was taken half hour before first training session and 24 hours after the last training session. t-test was used for data analyses. Statistical significance was set at P<0.05.

Results: The findings of the present study revealed that concurrent training increases TRF1 and TRF2 protein levels significantly (P=0.005 and P=0.006, respectively).

Conclusion: It seems that rehabilitation training improves shelterin complex and enhances protection of the telomere and as a result, induces better repair of infarcted area. Therefore, rehabilitation training could be suggested to myocardial infarction patients as a non-pharmacological treatment.

Introduction: Telomeres are DNA portions that are located on the two ends of the chromosome. Telomeres play an important role in cellular life. Exercise is one of the factors that contributes to their control. The purpose of the present study was to investigate the effect of 8 weeks of high intensity interval training (HIIT) on telomere length and telomerase activity in non-athletic young men.
Materials and methods: 30 inactive students were selected as sample and randomly divided into two groups of exercise (15 people) and control (15 people) in this semi-experimental study. The exercise group performed 8 weeks of HIIT exercise in 3 sessions per week with an intensity of 150 to 175% of their maximum power (Pmax). Control group subjects did not do regular sport activities. To measure telomere length and telomerase activity, 10 ml of blood was taken from the brachial vein of the subjects 24 hours before the first and after the last exercise session. The dependent t was used to analyze intra-group and independent t for within-group differences.
Results: The findings of this study showed that 8 weeks of HIIT training in non-athlete young men resulted in a significant increase in telomere length (P = 0.001) and telomerase activity (P = 0.001).