%0 Journal Article %A Rostami, Esmaeil %A Ayatollahi, Hossein %A Boustani, Hassan %A Ghotaslou, Abbas %A Sadeghian, Mohammad Hadi %A Keramati, Mohammad Reza %A Zeinali, Elahe %A Rad, Abolfazl %T Evaluation of PPP2R5C gene expression in Iranian patients with B-Acute lymphoblastic leukemia and its association with clinical and laboratory findings %J Journal of Basic Research in Medical Sciences %V 4 %N 4 %U http://jbrms.medilam.ac.ir/article-1-287-en.html %R 10.29252/jbrms.4.4.8 %D 2017 %K B-Acute Lymphoblastic Leukemia, PPP2R5C, PP2A, Gene expression, %X Introduction: PPP2R5C is one of the regulatory B subunits of protein phosphatase 2A (PP2A), which is a tumor suppressor. PPP2R5C plays a critical role in cell proliferation, differentiation, and transformation. Considering these vital functions, we investigate the gene expression in Iranian patients with B-Acute Lymphoblastic Leukemia (B-ALL) and its association with clinical and laboratory finding. Materials and methods: In this case-control study, peripheral blood samples were collected from 60 B-ALL patients and 30 healthy controls. PPP2R5C expression levels were determined by Real-time PCR. After calculation of CT for target and control genes, we calculated ΔCT. Finally we compared the PPP2R5C expression levels in patients with control group. Results: Significantly higher expression of PPP2R5C was found in the B-ALL patients (2.15±2. 50) compared with control group. There was no correlation between PPP2R5C expression and clinical and laboratory findings and FAB (French-American-British) subtype of patients. Conclusion: we demonstrated PPP2R5C overexpression in B-ALL patients. Although there was no significant correlation between PPP2R5C expression, clinical and laboratory finding and also with FAB subtypes of patients. %> http://jbrms.medilam.ac.ir/article-1-287-en.pdf %P 8-12 %& 8 %! %9 Research %L A-10-271-1 %+ Department of Hematology, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran %G eng %@ 2383-0506 %[ 2017