TY - JOUR JF - Ilam-University-of-Medical-Sciences JO - VL - 4 IS - 4 PY - 2017 Y1 - 2017/9/01 TI - Evaluation of PPP2R5C gene expression in Iranian patients with B-Acute lymphoblastic leukemia and its association with clinical and laboratory findings TT - N2 - Introduction: PPP2R5C is one of the regulatory B subunits of protein phosphatase 2A (PP2A), which is a tumor suppressor. PPP2R5C plays a critical role in cell proliferation, differentiation, and transformation. Considering these vital functions, we investigate the gene expression in Iranian patients with B-Acute Lymphoblastic Leukemia (B-ALL) and its association with clinical and laboratory finding. Materials and methods: In this case-control study, peripheral blood samples were collected from 60 B-ALL patients and 30 healthy controls. PPP2R5C expression levels were determined by Real-time PCR. After calculation of CT for target and control genes, we calculated ΔCT. Finally we compared the PPP2R5C expression levels in patients with control group. Results: Significantly higher expression of PPP2R5C was found in the B-ALL patients (2.15±2. 50) compared with control group. There was no correlation between PPP2R5C expression and clinical and laboratory findings and FAB (French-American-British) subtype of patients. Conclusion: we demonstrated PPP2R5C overexpression in B-ALL patients. Although there was no significant correlation between PPP2R5C expression, clinical and laboratory finding and also with FAB subtypes of patients. SP - 8 EP - 12 AU - Rostami, Esmaeil AU - Ayatollahi, Hossein AU - Boustani, Hassan AU - Ghotaslou, Abbas AU - Sadeghian, Mohammad Hadi AU - Keramati, Mohammad Reza AU - Zeinali, Elahe AU - Rad, Abolfazl AD - Department of Hematology, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran KW - B-Acute Lymphoblastic Leukemia KW - PPP2R5C KW - PP2A KW - Gene expression UR - http://jbrms.medilam.ac.ir/article-1-287-en.html DO - 10.29252/jbrms.4.4.8 ER -