%0 Journal Article %A Hoseini, Seyed nabiyollah %A Abbassi Daloii, Asieh %A Ziaolhagh, Seyed Javad %A Saeidi, Ayoub %T The effect of aerobic exercise and a synthesized insulin nanocomposite hydrogel on TNF-α and IL-6 in plasma of type 1 diabetic rats %J Journal of Basic Research in Medical Sciences %V 7 %N 2 %U http://jbrms.medilam.ac.ir/article-1-437-en.html %R %D 2020 %K Aerobic training, Synthesized insulin nanocomposite hydrogel, TNF-α, IL-6, Type 1 diabetic rat, %X Introduction: Diabetes is one of the leading causes of mortality in the world. The present study aimed to investigate the effect of aerobic exercise training and a synthesized insulin nanocomposite hydrogel on TNF-α and IL-6 in type 1 diabetic rats. Materials and methods: Twenty-five rats were divided into five equal groups of animals each containing five animals, control - healthy, Control-diabetes, Nano-insulin Diabetes, Exercise Diabetes and Nano-insulin Diabetes-Exercise. The exercise training program lasted eight weeks. After the five days of familiarization, exercise time for the exercise groups were as follows: 20 m/min for the first and second weeks, 25 m/min for the third and fourth weeks and 30 m / min for the fifth and sixth weeks. The rats were also given the Nano-insulin supplement. Rats were killed 48 hours after the last training session. Their plasma was taken and used for the analysis of markers. Results: There were significant differences in IL-6 (P<0.001) and TNF-α (P<0.001) between the groups. Conclusion: The results of this study showed that aerobic exercise training along with Nano-insulin supplementation significantly reduced TNF-α and IL-6 in rats with type 1 diabetes and these changes were more in the Nano-insulin Diabetes group. %> http://jbrms.medilam.ac.ir/article-1-437-en.pdf %P 38-46 %& 38 %! %9 Research %L A-10-361-3 %+ Department of Exercise Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran %G eng %@ 2383-0506 %[ 2020