%0 Journal Article %A Parastesh, Mohammad %A Bayatiani, Mohammadreza %A Khaleghi, Mina %A Sadeghian Shahi, Mohammadreza %A Ayatizadeh Tafti, Farahnaz %A Aria, Behzad %T The effect of high-intensity interval training on inflammatory markers in male rats undergoing X-ray radiation %J Journal of Basic Research in Medical Sciences %V 9 %N 1 %U http://jbrms.medilam.ac.ir/article-1-639-en.html %R %D 2022 %K X-ray radiation, High-intensity interval training, TNF-α, IL-6, %X Introduction: One of the famous cancer treatments that are associated with an increment in inflammatory factors is X-ray radiation. This study aimed to evaluate the effect of high-intensity interval training on inflammatory markers in male rats undergoing X-ray radiation. Materials and Methods: In this experimental study, 24 male rats were randomly divided into 4 groups: healthy control (n=6), HIIT (n=6), X-ray radiation (n=6) and X-ray radiation + HIIT (n=6). first, X-ray radiation and HIIT + X-ray radiation groups were anesthetized with ketamine xylazine solution (K, 60-90 kg/mg; Z, 6-10 kg/mg) and then placed on a 1 cm thick Plexiglas plate. The X-ray radiation photon beam was performed using X-ray with 4 Gy linear accelerators (Elekta Compact 6-MV China). The training program included ten weeks of HIIT. Serum levels of Tumor Necrosis Factor Alpha (TNF-α) and Interleukin-6 (IL-6) were measured by rat ELISA Kits. One-way ANOVA was used to determine the existence of a significant difference among groups. Results: The results showed a significant difference between TNF-α and IL-6 in the HIIT, X-ray radiation, and HIIT + X-ray radiation groups with the control group (P < 0.05), but there was no significant difference between these three groups (P > 0.05). Conclusion: X-ray radiation can increase TNF-α and IL-6. HIIT, on the other hand, can also enhance these factors. It seems better for people undergoing radiotherapy to use another exercise training instead of HIIT. %> http://jbrms.medilam.ac.ir/article-1-639-en.pdf %P 10-18 %& 10 %! %9 Research %L A-10-512-4 %+ Department of Physical Education and Sports Science, School of Psychology and Educational Sciences, Yazd University, Yazd, Iran %G eng %@ 2383-0506 %[ 2022