Journal of Basic Research in Medical Sciences

en Clinical Utility of Serum Opalin in Traumatic Brain Injury Clinical Biochemistry Clinical Biochemistry پژوهشي Research Introduction: Despite traumatic brain injury (TBI) being a leading cause of global morbidity and mortality, it lacks easy-to-access or portable, reliable biomarkers for early diagnosis. This study was designed to evaluate serum Opalin, a CNS-specific protein, in drug-naïve TBI patients. Materials & Methods: Conducted as a prospective case-control study at a tertiary care setting, 60 drug-naïve TBI patients and 60 healthy controls (HC) were evaluated for serum Opalin levels. Results:  TBI patients showed significant alterations in serum Opalin levels. Opalin demonstrated high diagnostic accuracy (AUC: 0.943) with 86.67% sensitivity and 95% specificity at a cut-off of 321.7 pg/mL. Strong correlations were found between Opalin levels and TBI severity (using CT scan and Glasgow coma scale score). Conclusion:  This research underscores the potential application of serum Opalin to augment current evaluation methods like CT scan and Glasgow coma scale evaluations.   Traumatic Brain Injury (TBI), Serum, Opalin, Biomarkers, Diagnosis 100 109 http://jbrms.medilam.ac.ir/browse.php?a_code=A-10-1526-2&slc_lang=en&sid=1 Saba Farhadian 10031947532846008110 0009-0009-0072-9540 No Department of Clinical Biochemistry, Faculty of Medicine, Ilam University Medical Sciences, Ilam, Iran Ali Noori-Zadeh alincbc@gmail.com 10031947532846008111 10031947532846008111 No Department of Clinical Biochemistry, Faculty of Medicine, Ilam University Medical Sciences, Ilam, Iran Ali Seidkhani-Nahal 10031947532846008112 10031947532846008112 Yes Department of Clinical Biochemistry, Faculty of Medicine, Ilam University Medical Sciences, Ilam, Iran Masoud Hatefi 10031947532846008113 10031947532846008113 No Department of Neurosurgery, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran