en Physiology Physiology مقالات مروری Narrative review <span style="font-size:9pt"><span minion="" pro="" style="font-family:"><b>Introduction</b>: Myocardial infarction induces IRI, leading to cardiomyocyte necrosis, neutrophil-driven inflammation, and fibroblast-mediated fibrosis, culminating in ventricular dysfunction. Stem Cell such as MSCs promote angiogenesis via VEGF/HGF paracrine secretion; CPCs differentiate through Notch/Wnt for tissue replacement; iPSCs enable patient-specific remuscularization with Cx43 integration.</span></span><br> <span style="font-size:9pt"><span minion="" pro="" style="font-family:"><b>Aim</b><b><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times="">: </span></span></b>The purpose of this study is to investigate the role of stem cells in cardiac tissue repair after myocardial infarction via physiological mechanisms.<span lang="FA" dir="RTL" style="font-family:"Times New Roman","serif""></span></span></span><br> <span style="font-size:9pt"><span minion="" pro="" style="font-family:"><b>Discussion</b><b><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times="">: &nbsp;</span></span></b>Stem cell&ndash;based therapies represent a promising yet evolving approach for cardiac repair following myocardial infarction. Preclinical models consistently demonstrate improvements in angiogenesis, attenuation of fibrosis, and partial restoration of ventricular function; however, these outcomes have not been fully replicated in clinical trials.</span></span><br> <span style="font-size:9pt"><span minion="" pro="" style="font-family:"><b>Conclusion</b><b><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times="">: &nbsp;</span></span></b>This review synthesizes mechanisms for advancing clinical translation. the future of cardiac regenerative medicine lies in the integration of mechanistic insights with bioengineering and molecular innovation.</span></span> stem cells, heart tissue, Myocardial Infarction, physiological mechanisms 10 18 http://jbrms.medilam.ac.ir/browse.php?a_code=A-10-788-9&slc_lang=en&sid=1 AliReza pourrahim 10031947532846008422 0009-0004-4669-4033 No student research committee,faculty of medicine,ilam university of medical sciences Maryam Kheiry m.kheiry@yahoo.com 10031947532846008423 10031947532846008423 Yes Non-Communicable Diseases Research Center, Ilam University of Medical sciences, Ilam, Iran