Journal of Basic Research in Medical Sciences
مجله ی تحقیقات پایه در علوم پزشکی
Journal of Basic Research in Medical Sciences
Medical Sciences
http://jbrms.medilam.ac.ir
1
admin
2383-0506
2383-0972
doi
en
jalali
1395
10
1
gregorian
2017
1
1
4
1
online
1
fulltext
en
Effect of endurance exercise training on morphological changes in rat heart tissue following experimental myocardial infarction
Cardiovascular Diseases
Cardiovascular Diseases
پژوهشي
Research
<div dir="ltr">
<p style="text-align: justify;"><strong>Introduction: </strong>Cardiac remodeling after myocardial infarction, is associated with progressive ventricular dysfunction and cardiovascular death. The purpose of this study was to examine the effect of endurance exercise training on morphological changes in rat heart tissue following experimental myocardial infarction.</p>
<p style="text-align: justify;"><strong>Materials and methods:</strong> Rats used in this experiment (8-10 weeks old, 235 ± 5 g body weight) after homogenization according to body weight, were randomly divided to three groups: Healthy (Sham), control (Sedentary) and endurance training groups. Myocardial infarction was induced by subcutaneous injection of isoprenaline (150 mg/kg) in two consecutive days with an interval of 24 hours. Endurance training initiated 2 days after infarction and continued for 4 weeks. In order to assess the necrosis lesion and fibrosis tissue, Hematoxylin–Eosin and Masson's trichrome staining were used, respectively. Data were analyzed by using one-way analysis of variance (ANOVA) at P< 0.05 level.</p>
<p style="text-align: justify;"><strong>Results:</strong> The results indicated that subcutaneous injection of isoprenaline, induced myocardial infarction in rat heart tissue. Rate of necrotic lesion in the Endurance training group was significantly higher than Sedentary (control) group (P=0.005). Also, the size of fibrosis tissue in the Endurance training group was significantly higher than the sedentary (control) group (P= 0.001).</p>
<p style="text-align: justify;"><strong>Conclusion:</strong> In general, results of this study showed that 4 weeks of endurance exercise training after myocardial infarction exacerbate tissue injury in rat heart.</p>
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Endurance training, Myocardial infarction, Morphological changes, Rat
8
16
http://jbrms.medilam.ac.ir/browse.php?a_code=A-10-142-1&slc_lang=en&sid=1
Akbar
Azamian Jazi
abdi_197866@yahoo.com
10031947532846002052
10031947532846002052
No
Department of Exercise Physiology, Faculty of Literature and Human Sciences, Shahrekord University, Shahrekord, Iran
Hadi
Abdi
azamianakbar@yahoo.com
10031947532846002053
10031947532846002053
Yes
Department of Physical Education, Payam-e-noor University, Tehran, Iran
Mohammad Reza
Haffezi Ahmadi
reza.ahmadi56@yahoo.com
10031947532846002054
10031947532846002054
No
Department of Pathobiology, Faculty of Medicine, Ilam University of Medical Science, Ilam, Iran
Javad
Cheraghi
j.cheraghi@ilam.ac.ir
10031947532846002055
10031947532846002055
No
Department of Physiology, Faculty of Veterinary Medicine, Ilam University, Ilam, Iran