Journal of Basic Research in Medical Sciences
مجله ی تحقیقات پایه در علوم پزشکی
Journal of Basic Research in Medical Sciences
Medical Sciences
http://jbrms.medilam.ac.ir
1
admin
2383-0506
2383-0972
doi
en
jalali
1394
10
1
gregorian
2016
1
1
3
1
online
1
fulltext
en
Hormonal changes in women with breast cancer infected with Toxoplasma gondii
Parasitologiy
Parasitologiy
پژوهشي
Research
<div dir="ltr">
<p style="text-align: justify"><strong>Introduction:</strong> Acute Toxoplasmosis is more critical in immunocompromised patients with cancer. The present study was conducted to investigate the anti-Toxoplasma gondi antibodies and assess the toxoplasmosis risk in women with breast masses in western of Iran in 2012. This research was done as a case-control study on women who referred to the treatment centers in cities of Kermanshah and Ilam in 2011.</p>
<p style="text-align: justify"><strong>Materials and methods:</strong> 60 women with breast cancer were selected as cases, and also 60 healthy ones as the control group. They were evaluated in terms of IgG, IgM, estrogen and progesterone levels using immunoassay method. Women in this study were in the secretory phase and were under the age of menopause. Results were analyzed using SPSS software 16 with independent T test.</p>
<p style="text-align: justify"><strong>Results:</strong> Relationship between Toxoplasma gondii (T. gondii) infection and breast cancer was statistically significant (P<0.01). There was a significant relationship between anti-Toxoplasma IgG antibody and breast cancer (P=0.01). Women with breast cancer and healthy women were not reported positive in terms of IgM anti-Toxoplasma. Significant relationship was detected between estrogen and Toxoplasma in women with breast cancer (P<0.01). There was no significant relationship between the level of progesterone and anti-Toxoplasma antibodies. A total of 30 patients (50%) from the women under study had the tumor marker CEA 19-9 (Carcino embryonic antigen).</p>
<p style="text-align: justify"><strong>Conclusion:</strong> Patients with breast tumors may be at risk of opportunistic infections such as toxoplasmosis. Therefore, periodic examination of breast cancer patients should be conducted by clinicians to prevent the potential occurrence of toxoplasmosis.</p>
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Hormones changes, Toxoplasma gondii, Breast cancer
16
21
http://jbrms.medilam.ac.ir/browse.php?a_code=A-10-127-3&slc_lang=en&sid=1
Laila
Aabasian
taniaabasian@ymail.com
10031947532846002644
10031947532846002644
No
Department of Parasitology, Ilam University of Medical Sciences, Ilam, Iran
Shahnaz
Shirbazou
s.shirbazou@yahoo.com
10031947532846002645
10031947532846002645
Yes
2. Department of Parasitology, Baqiyatallah University of Medical Sciences, Tehran, Iran
Morteza
Shamsi
Sara.damghani@yahoo.com
10031947532846002646
10031947532846002646
No
Medical Student, Shahid Beheshti University of Medical Science, Tehran,Iran
Sara
Damghani
alidelpisheh@yahoo.com
10031947532846002647
10031947532846002647
No
4. Department of Epidemiology &Prevention of Psychosocial Injuries, Research Centre, Ilam University of Medical Sciences, Ilam, Iran
Ali
Delpisheh
Shamsi_ilam@yahoo.com
10031947532846002648
10031947532846002648
No
Department of Parasitology, Ilam University of Medical Sciences, Ilam,Iran