en Hematology Hematology پژوهشي Research <div> <p><strong>Introduction: </strong>PPP2R5C is one of the regulatory B subunits of protein phosphatase 2A (PP2A), which is a tumor suppressor. PPP2R5C plays a critical role in cell proliferation, differentiation, and transformation. Considering these vital functions, we investigate the gene expression in Iranian patients with B-Acute Lymphoblastic Leukemia (B-ALL) and its association with clinical and laboratory finding.</p> <p><strong>Materials and methods:</strong> In this case-control study, peripheral blood samples were collected from 60 B-ALL patients and 30 healthy controls. PPP2R5C expression levels were determined by Real-time PCR. After calculation of CT for target and control genes, we calculated &Delta;CT. Finally we compared the PPP2R5C expression levels in patients with control group.</p> <p><strong>Results:</strong> Significantly higher expression of PPP2R5C was found in the B-ALL patients (2.15&plusmn;2. 50) compared with control group. There was no correlation between PPP2R5C expression and clinical and laboratory findings and FAB (French-American-British) subtype of patients.</p> <p><strong>Conclusion: </strong>we demonstrated PPP2R5C overexpression in B-ALL patients. Although there was no significant correlation between PPP2R5C expression, clinical and laboratory finding and also with FAB subtypes of patients.</p> </div> B-Acute Lymphoblastic Leukemia, PPP2R5C, PP2A, Gene expression 8 12 http://jbrms.medilam.ac.ir/browse.php?a_code=A-10-271-1&slc_lang=en&sid=1 Esmaeil Rostami a.ghotaslou@gmail.com 10031947532846002598 10031947532846002598 No Department of Laboratory Sciences, Faculty of Paramedicine, Sabzevar University of Medical Sciences, Sabzevar, Iran Hossein Ayatollahi a.ghotaslou@gmail.com 10031947532846002599 10031947532846002599 No Cancer Molecular Pathology Research Center, Department of Hematology and Blood Bank, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Hassan Boustani a.ghotaslou@gmail.com 10031947532846002600 10031947532846002600 No Department of Hematology, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran Abbas Ghotaslou a.ghotaslou@gmail.com 10031947532846002601 10031947532846002601 Yes Department of Hematology, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran Mohammad Hadi Sadeghian a.ghotaslou@gmail.com 10031947532846002602 10031947532846002602 No Neonatal Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Mohammad Reza Keramati a.ghotaslou@gmail.com 10031947532846002603 10031947532846002603 No Neonatal Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Elahe Zeinali a.ghotaslou@gmail.com 10031947532846002604 10031947532846002604 No Department of laboratory sciences, Faculty of Paramedicine, Mashhad University of Medical Sciences, Mashhad, Iran Abolfazl Rad a.ghotaslou@gmail.com 10031947532846002605 10031947532846002605 No Department of Biochemistry and Nutrition, Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran