en Physiology Physiology پژوهشي Research <div><strong>Introduction: </strong>Aging and low physical activity results in a decrease in Adiponectin and an increase in leptin, which can cause cardiovascular diseases, obesity and diabetes. The aim of present study was to investigate the effect of 8 weeks circuit-resistance training (CRT) with Zataria multiflora (<em>Z. multiflora</em>) supplementation on plasma leptin and adiponectin in postmenopausal women.<br> <strong>Materials and methods:</strong> 48 untrained postmenopausal women took part in this study. The participants were randomly divided in 4 groups with 12 persons in each: resistance training (RTG), <em>Z. multiflora</em> (ZG), control (CG) and <em>Z. multiflora</em>- resistance training (ZRTG). Resistance training program contained 12 stations (each station 30 second with 35 percent of one maximum repetition) and continued for 8 weeks (3 sessions per week). Participants in the ZG and ZRTG consumed 500 mg of <em>Z. multiflora</em> supplementation daily before breakfast. Blood samples were collected 48 hours before first session and 48 hours after last session to measure plasma levels of leptin and Adiponectin.<br> <strong>Results:</strong> Significant difference between ZRTG and CG in plasma Adiponectin was observed (P˂0.05). However, there was no significant difference between groups in leptin (P˃0.05).</div> <strong>Conclusion: </strong>This study indicated that CRT can cause a decrease in leptin and an increase in Adiponectin. Also, when <em>Z. multiflora</em> intervention included in the training program, this effects increased. Circuit-resistance training, Zataria multiflora supplementation, Adiponectin, Leptin, Postmenopausal women 21 30 http://jbrms.medilam.ac.ir/browse.php?a_code=A-10-302-1&slc_lang=en&sid=1 Ayoub Saeidi gharahcholo@yahoo.com 10031947532846003155 10031947532846003155 No Exercise Biochemistry Division, Faculty of Physical Education and Sport Sciences, University of Mazandaran, Babolsar, Mazandaran, Iran Hassane Zouhal souri348@yahoo.com 10031947532846003156 10031947532846003156 No University of Rennes, M2S (Movement Sports Science Laboratory), Rennes, France Akbar Nouri-Habashi Mahnosh_sa@yahoo.com 10031947532846003157 10031947532846003157 Yes Department of Sport and Exercise Physiology, Faculty of Sports Sciences, Urmia University, Urmia, Iran Souri Heydari m83.ahmadi@gmail.com 10031947532846003158 10031947532846003158 No Department of Physical Education and Sport Science, Payame Noor University, Iran Mahnoosh Salarinahand akbarnori52@gmail.com 10031947532846003159 10031947532846003159 No Department of Physical Education and Sport Science, Hakim Ferdosi Pardis, Farhangian University, Iran Mahtab Ahmadi 10031947532846003160 10031947532846003160 No Department of Exercise Physiology, Faculty of Physical Education and Sport Science, Karaj Payam Noor University, Karaj, Iran Fatemeh Malekian 10031947532846003161 10031947532846003161 No Professor and Director, Southern University Agricultural Land Grant Campus, Baton Rouge Louisiana, USA