en Microbiology Microbiology پژوهشي Research <div><strong>Introduction:</strong> In the study we sought to determine the patterns of regional antibiotic resistances among uropathogenic <em>Escherichia coli</em> (UPEC) isolates. Our finding could be useful for better recognition of regional antibiotic resistances and scheduling a program to control this condition.<span dir="RTL"></span><br> <strong>Materials and methods:</strong> In the study, 270 nonduplicate UPEC isolates were examined from urine samples of outpatients with urinary tract infections (UTIs). All isolates were identified by gram staining and standard conventional biochemical tests. Antimicrobial susceptibility test was performed by disk diffusion (Kirby&ndash;Bauer) method. The commercial antibiotics disks (PADTAN TEB Co., Iran) were applied in the study, included amikacin (30 &mu;g), gentamycin (10 &mu;g), ciprofloxacin (5 &mu;g), and nalidixic acid (30 &mu;g).<br> <strong>Results:</strong> Most of the patients were female (221, 81.9%). The highest resistance was observed for nalidixic acid (56%), followed by ciprofloxacin 39.64%. In contrast, the lowest resistance was seen for amikacin (3.90%) and gentamicin (10.04%). Moreover, 19.62% of the isolates were multidrug-resistant (MDR).<br> <strong>Conclusion: </strong>Amikacin and gentamicin could be chosen as first line antibiotics in treatment of UTIs. Continuous monitoring studies recommended for acquire a suitable regional antibiotic resistance pattern.</div> Escherichia coli, UTIs, Antimicrobial susceptibility 7 12 http://jbrms.medilam.ac.ir/browse.php?a_code=A-10-119-1&slc_lang=en&sid=1 Saeed Hemati saeedhemati0064@gmail.com 10031947532846003807 10031947532846003807 No Zoonotic Diseases Research Center, Ilam University of Medical Sciences, Ilam, Iran Morteza Shams fmaleki88@yahoo.com 10031947532846003808 10031947532846003808 No Zoonotic Diseases Research Center, Ilam University of Medical Sciences, Ilam, Iran Arash Rahmatian Ar.sana2009@yahoo.com 10031947532846003809 10031947532846003809 No Zoonotic Diseases Research Center, Ilam University of Medical Sciences, Ilam, Iran Hasan Nourmohammadi hnm51.hn@gmail.com 10031947532846003810 10031947532846003810 No Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran Amir Abdoli zahramahdavi9165@gmail.com 10031947532846003811 10031947532846003811 No Department of Parasitology, Faculty of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran Farajolah Maleki E.bastani@yahoo.com 10031947532846003812 10031947532846003812 No Zoonotic Diseases Research Center, Ilam University of Medical Sciences, Ilam, Iran Ghasem Talee v.hatami1392@gmail.com 10031947532846003813 10031947532846003813 No Clinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam, Iran Zahra Mahdavi fkohzadi00@gmail.com 10031947532846003814 10031947532846003814 No Clinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam, Iran Elham Bastani 10031947532846003815 10031947532846003815 No Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran Vahid Hatami 10031947532846003816 10031947532846003816 No Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran Fatemeh Kohzadi 10031947532846003817 10031947532846003817 Yes Zoonotic Diseases Research Center, Ilam University of Medical Sciences, Ilam, Iran