en Microbiology Microbiology پژوهشي Research <div><strong>Introduction: </strong>Oral diseases are among the most important worldwide infectious diseases. Due to drug resistance and the side effects of chemical drugs, the use of herbal medicines has increased. <em>Scrophularia striata </em>(<em>S. striata</em>)<em> is</em> a herbal flowering plant that is used in microbial infections. Therefore, this study aimed to evaluate the antimicrobial activity of <em>S. striata</em> essential oil on dental carrier&rsquo;s pathogens.<br> <strong>Materials and Methods:</strong> In this study, <em>S. striata</em> essential oil was prepared and its antimicrobial activity was evaluated by disk diffusion, minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC) methods on dental caries pathogens <em>Streptococcus mutans </em>(<em>S. mutans</em>), <em>Lactobacillus rhamnosus </em>(<em>L. rhamnosus</em>), <em>Actinomyces viscosus </em>(<em>A. viscosus</em>), and <em>Candida albicans </em>(<em>C. albicans</em>). Moreover, the chemical composition of <em>S. striata</em> essential oil was evaluated by gas chromatography-mass spectrometry (GC-MS) method.<br> <strong>Results:</strong> Our results showed that the most antibacterial activity of <em>S. striata </em>essential oil was related to <em>A. viscosus </em>(22.9 mm), <em>L. rhamnosus </em>(21.7 mm), and <em>S. mutans</em> (16.9 mm) essential oil showed a low antifungal activity against <em>C. albicans</em>. The dominant chemical composition of <em>S. striata </em>essential oil was terpens (39.8%).<br> <strong>Conclusion:</strong>&nbsp; In general, <em>S. striata </em>essential oil has an appropriate antibacterial activity against oral pathogens. Therefore, it can be use in pharmaceutical industry to produce antimicrobial agents against dental caries and oral infectious diseases.</div> Dental caries Antimicrobial, Scrophularia striata, Essential oil 36 42 http://jbrms.medilam.ac.ir/browse.php?a_code=A-10-503-1&slc_lang=en&sid=1 Shahram Dadelahi sh.dadelahi@gmail.com 10031947532846004120 10031947532846004120 No Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran Farnaz Yousefi farnazyousefi@yahoo.com 10031947532846004121 10031947532846004121 No Department of Microbiology, Urmia Branch, Islamic Azad University, Urmia, Iran Parisa Emami Golmarz emami.parisa@yahoo.com 10031947532846004122 10031947532846004122 No Department of Genetics, Ahar Branch, Islamic Azad University, Ahar, Iran Elham Taheri elham.taheri1366@gmail.com 10031947532846004123 10031947532846004123 Yes Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran