Journal of Basic Research in Medical Sciences
مجله ی تحقیقات پایه در علوم پزشکی
Journal of Basic Research in Medical Sciences
Medical Sciences
http://jbrms.medilam.ac.ir
1
admin
2383-0506
2383-0972
doi
en
jalali
1400
3
1
gregorian
2021
6
1
8
3
online
1
fulltext
en
The effect of aerobic exercise combined with bone marrow mesenchymal stem cells on inflammatory biomarkers levels of the brain in a model of osteoarthritic rat
Physiology
Physiology
پژوهشي
Research
<div><strong>Introduction: </strong>Osteoarthritis is a degenerative disease that has many public health problems. Interleukin 10 (IL-10) and tumor necrosis factor alfa (TNF-α) are considered as the main factors regulating inflammation and pathology of knee osteoarthritis. This study was done to investigate the effects of <a name="_Hlk69377404">mesenchymal stem cells (MSCs)</a> and aerobic training on inflammatory biomarkers (IL-10 and TNF- α) in the brain tissue of osteoarthritic rats.<br>
<strong>Materials and Methods: </strong>In this experimental study, 48 male Wistar rats were randomly divided into six groups (n=8 in each group) as follows: 1. Naive (healthy control), 2. Osteoarthritis (Ost), 3. Osteoarthritis + saline (Sal), 4. Osteoarthritis + mesenchymal cells (Mes), 5. Osteoarthritis + training (Tra), and 6. Osteoarthritis + training + mesenchymal cells (Tra + Mes). An essential aerobic exercise program was performed for eight weeks as follows: Speed: 15-22 meters per minute; Slope: 0<sup>o</sup> for 25-64 minutes. Inflammatory biomarkers, including TNF-α and IL-10 cytokines, in the brain tissue of rats, were measured using enzyme-linked immunosorbent assay.<br>
<strong>Results: </strong>The combination of training and treatment with MSCs in the brain of osteoarthritic rats significantly increased the level of IL-10 in comparison with the use of MSCs or aerobic exercise alone. Moreover, the combined use of exercise and MSCs caused a significant decrease in TNF-α concentration.<br>
<strong>Conclusion: </strong>It seems that the combined use of MSCs and eight weeks of aerobic exercise improves the concentration of inflammatory biomarkers in the brain of a rat model of osteoarthritis.</div>
Exercise, Osteoarthritis, Inflammation, Stem cells
32
39
http://jbrms.medilam.ac.ir/browse.php?a_code=A-10-504-1&slc_lang=en&sid=1
Mohamad
Fatahi
mohamadfatahi02@gmail.com
10031947532846004447
10031947532846004447
No
Department of Exercise Physiology, Kermanshah Branch, Islamic Azad University, Kermanshah, Iran
Naser
Behpoor
n_behpoor@yahoo.com
10031947532846004448
10031947532846004448
Yes
Department of Exercise Physiology, Razi University, Kermanshah, Iran
Sedighe
Hosseinpourdelavar
delavar2009@yahoo.com
10031947532846004449
10031947532846004449
No
Department of Exercise Physiology, Kermanshah Branch, Islamic Azad University, Kermanshah, Iran
Parvin
Farzaneghi
parvin.farzanegi@gmail.com
10031947532846004450
10031947532846004450
No
Department of Exercise Physiology, Sari Branch, Islamic Azad University, Sari, Iran