en Immunology Immunology مقالات مروری Narrative review Ulcerative colitis (UC), multiple sclerosis (MS), and Kawasaki disease (KD) are three autoimmune diseases that involve the colon mucosa, myelin of the central nervous system neurons, and vascular epithelium. All these diseases need invasive, expensive, and complex modalities or criteria in order to monitor the disease severity. Recently, the neutrophil-to-lymphocyte ratio (NLR) has been proposed as a valuable, cheap, and easy marker of systemic inflammation. As all the above-mentioned diseases involve neutrophils and lymphocytes as the two major cell lines, it may be applicable to assess their severity according to the NLR. Here, we review the available literature with this regard. Neutrophil to lymphocyte ratio, Ulcerative colitis, Multiple sclerosis, Kawasaki disease 62 70 http://jbrms.medilam.ac.ir/browse.php?a_code=A-10-488-2&slc_lang=en&sid=1 Alireza Ghodsi ghodsia921@mums.ac.ir 10031947532846003981 10031947532846003981 No Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Mohammad Mobin Mirimoghaddam Mobinmiri@gmail.com 10031947532846003982 10031947532846003982 No Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Mehrdad Sarabi sarabim921@mums.ac.ir 10031947532846003983 10031947532846003983 No Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Amirreza Dehghan Tarazjani dehghanta921@mums.ac.ir 10031947532846003984 10031947532846003984 No Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Alireza Omranzadeh omranzadeha@gmail.com 10031947532846003985 10031947532846003985 No Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Masoud Mahdavi Rashed mahdavirm@mums.ac.ir 10031947532846003986 10031947532846003986 No Department of Radiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Hamid Reza Rahimi rahimihamidrezaa@gmail.com 10031947532846003987 10031947532846003987 Yes Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran