Journal of Basic Research in Medical Sciences
مجله ی تحقیقات پایه در علوم پزشکی
Journal of Basic Research in Medical Sciences
Medical Sciences
http://jbrms.medilam.ac.ir
1
admin
2383-0506
2383-0972
doi
en
jalali
1400
12
1
gregorian
2022
3
1
9
2
online
1
fulltext
en
The effect of eight weeks of HIIT on some angiogenesis indices of apelin-13 in elderly male rats
Physiology
Physiology
پژوهشي
Research
<div style="border-bottom:solid windowtext 1.0pt; border-top:solid windowtext 1.0pt; border-left:none; border-right:none; padding:1.0pt 0in 0in 0in"><span style="background:white"><span style="font-size:11pt"><span style="background:white"><span style="line-height:normal"><span style="text-autospace:none"><span style="unicode-bidi:embed"><span style="font-family:"Calibri",sans-serif"><b><span style="font-family:"Times New Roman",serif"><span style="color:black">Introduction: </span></span></b><span style="font-family:"Times New Roman",serif"><span style="color:black">Aging causes changes in metabolic, cardiovascular, and neuromuscular functions. By developing aging process, physical activity decreases, which is mainly due to fundamental changes in body composition and lack of angiogenesis for which some indicators of angiogenesis have been found in older male mice. The purpose of this study was to investigate the effect of high-intensity interval training (HIIT) on angiogenesis indices in elderly male rats.</span></span><span style="font-family:"Times New Roman",serif"></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="background:white"><span style="line-height:normal"><span style="text-autospace:none"><span style="unicode-bidi:embed"><span style="font-family:"Calibri",sans-serif"><b><span style="font-family:"Times New Roman",serif"><span style="color:black">Materials and Methods:</span></span></b> <span style="font-family:"Times New Roman",serif"><span style="color:black">The studied sample included 20 elderly male mice, which were randomly divided into two groups of control (n = 10) and experimental (n = 10). The experimental group repeated the HIIT in the specified intervals. The exercises were repeated after two minutes of rest, with 80% of the maximum speed in the first week, 90% in the second week, 100% in the third week, and 110% from the beginning of the fourth week, until the end of the training. To evaluate the research variables (VEGF, FGF21, NO, apelin-13), 3 ml of peripheral blood was drawn from the tail of elderly male mice 72 hours before and after the last session of the training. </span></span><span dir="RTL" style="font-family:"Times New Roman",serif" lang="FA"></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="background:white"><span style="line-height:normal"><span style="text-autospace:none"><span style="unicode-bidi:embed"><span style="font-family:"Calibri",sans-serif"><b><span style="font-family:"Times New Roman",serif"><span style="color:black">Results: </span></span></b><span style="font-family:"Times New Roman",serif"><span style="color:black">Eight weeks of HIIT significantly increased VEGF and NO (P = 0.001). It also increased the FGF and apelin-3 levels significantly (P = 0.0001). No significant change was observed in the control group.</span></span><span style="font-family:"Times New Roman",serif"></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="background:white"><span style="line-height:normal"><span style="text-autospace:none"><span style="unicode-bidi:embed"><span style="font-family:"Calibri",sans-serif"><b><span style="font-family:"Times New Roman",serif"><span style="color:black">Conclusion: </span></span></b><span style="font-family:"Times New Roman",serif"><span style="color:black">The results of this study showed that eight weeks of HIIT significantly increased angiogenesis levels in elderly male rats. Therefore, HIIT can be used as an appropriate and especially alternative exercise to increase angiogenesis in the elderly individuals.</span></span><span style="font-family:"Times New Roman",serif"></span></span></span></span></span></span></span></span></div>
HIIT, VEGF, FGF21, Apelin-13, Angiogenesis, Elderly
35
42
http://jbrms.medilam.ac.ir/browse.php?a_code=A-10-533-1&slc_lang=en&sid=1
Golbano
Blori
sbloory@yahoo.com
10031947532846004900
10031947532846004900
No
Department of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran
Hossein
Abednatanzi
abednazari@gmail.com
10031947532846004901
10031947532846004901
Yes
Department of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran
Hojjat Allah
Nikbakht
hojnik1937@yahoo.com
10031947532846004902
10031947532846004902
No
Department of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran