en Physical medicine Physical medicine پژوهشي Research <span style="font-size:9pt"><span minion="" pro="" style="font-family:"><b>Introduction</b>: Osteoporosis, characterized by diminished bone mass and increased fracture susceptibility, prompts the investigation into the impact of a four-month TRX training regimen on femur neck bone mineral density (BMD) and its correlation with serum leptin levels in women with osteopenia.</span></span><br> <span style="font-size:9pt"><span minion="" pro="" style="font-family:"><b>Material & Methods</b>: In this quasi-experimental study, 30 women with osteopenia were purposefully selected and randomly assigned to TRX training (n = 15) or control (n = 15) groups. The intervention group underwent TRX exercises thrice weekly for 45-60 minutes per session for four months. Blood samples collected at baseline and post-intervention measured serum leptin levels via ELISA kit (Bio vendor, Czech Republic), while Dexa Lexxos Digital (2D model, USA) determined femur neck BMD. SPSS 20 software, dependent/independent samples t-tests, and Pearson correlation were used for data analysis.</span></span><br> <span style="font-size:9pt"><span minion="" pro="" style="font-family:"><b>Results</b>: TRX training significantly increased femur neck BMD, reducing serum adiponectin levels versus the control group (P = 0.001 and P = 0.01, respectively). Compared to baseline, TRX training raised femur neck BMD and lowered serum leptin levels (P = 0.000 and P = 0.01, respectively). A significant inverse correlation emerged between femoral neck BMD and serum leptin levels in women with osteopenia (P = 0.00).</span></span><br> <b><span style="font-size:11.0pt"><span style="line-height:97%"><span calibri="" style="font-family:">Conclusion</span></span></span><span style="font-size:11.0pt"><span style="line-height:97%"><span new="" roman="" style="font-family:" times="">: </span></span></span></b><span style="font-size:11.0pt"><span style="line-height:97%"><span calibri="" style="font-family:">Findings suggest that TRX resistance training holds promise for enhancing the rehabilitation of women with osteopenia</span></span></span> Osteopenia, TRX Exercise, Femur Neck Bone Mineral Density, Leptin 34 44 http://jbrms.medilam.ac.ir/browse.php?a_code=A-10-173-2&slc_lang=en&sid=1 Fatemeh Poodineh f.poodineh97@gmail.com 10031947532846006899 10031947532846006899 No Department of Sport Sciences, Faculty of Education and Psychology, University of Sistan and Baluchestan, Zahedan, Iran Abbas Salehikia salehikia@ped.usb.ac.ir 10031947532846006900 10031947532846006900 Yes Department of Sport Sciences, Faculty of Education and Psychology, University of Sistan and Baluchestan, Zahedan, Iran Maryam Banparvari banparvari@ped.usb.ac.ir 10031947532846006901 10031947532846006901 No Department of Sport Sciences, Faculty of Education and Psychology, University of Sistan and Baluchestan, Zahedan, Iran Zahra Raghi z.raghi@ped.usb.ac.ir 10031947532846006902 10031947532846006902 No Department of Sport Sciences, Faculty of Education and Psychology, University of Sistan and Baluchestan, Zahedan, Iran