en Cellular and molecular biology Cellular and molecular biology پژوهشي Research <div><strong>A</strong><strong>bstract</strong><br> <strong>Introduction:</strong> Decreased physical activity is one of the main causes of the obesity epidemic. In the process of obesity, the secretion of some hepato-adipokines increases and causes metabolic disorders. Exercise plays an important role in improving the complications of obesity by regulating the levels of selected hepato-adipokine. The purpose of this study was to examine the effects of three types of resistance training methods on selected hepato-adipokine and lipid profiles in men with obesity.<br> <strong>Materials and Methods: </strong>The sample of the study included 44 sedentary men with obesity divided into 4 groups of traditional resistance training (TRT), circuit resistance training (CRT), and interval resistance training (IRT) as well as one control group. Fetuin-A, Fetuin-B, high-density lipoproteins (HDL), low-density lipoproteins (LDL), total cholesterol (TC), and triglyceride (TG) were measured using the ELISA method.<br> <a name="_Hlk83282040"><strong>Results</strong></a><strong>: </strong>The results of the mixed model ANOVA analysis showed a significant interaction between the type of training used and time at the levels of Fetuin-A (F (1, 40) = 94273.16, P = 0.001, ES = 1.00) and Fetuin-B (F (1, 40) = 49697.67, P = 0.001, ES = 0.99. In addition, within-group comparisons showed that lipid profile improved in TRT and CRT groups compared to the pretest (P = 0.001), while in the IRT group this improvement was not significant (P > 0.05). <span dir="RTL"></span><br> <a name="_Hlk85713844"><strong>Conclusion</strong></a>: The result of the present study shows that three models of resistance training reduced the select hepato-adipokines level in comparison to the control group. However, IRT and CRT had the greatest effect on reducing Fetuin-A and Fetuin-B, respectively.</div> Exercise, Adipose tissue, Hepato-adipokines, Fetuin-A, Fetuin-B, Metabolic disorder, Homeostasis 50 61 http://jbrms.medilam.ac.ir/browse.php?a_code=A-10-455-5&slc_lang=en&sid=1 Fatemeh Takalooei 10031947532846004771 10031947532846004771 No Department of Sport Science, Faculty of Humanities, Tarbiat Modares University, Tehran, Iran Shahnaz Shahrbanian sh.shahrbanian@modares.ac.ir 10031947532846004772 10031947532846004772 Yes Department of Sport Science, Faculty of Humanities, Tarbiat Modares University, Tehran, Iran Anthony C. Hackney 10031947532846004773 10031947532846004773 No Departments of Exercise and Sport Science, and Department of Nutrition, School of Public Health, University of North Carolina, Chapel Hill, USA