Journal of Basic Research in Medical Sciences
مجله ی تحقیقات پایه در علوم پزشکی
Journal of Basic Research in Medical Sciences
Medical Sciences
http://jbrms.medilam.ac.ir
1
admin
2383-0506
2383-0972
doi
en
jalali
1401
3
1
gregorian
2022
6
1
9
3
online
1
fulltext
en
Effect of resistance exercises and nano-curcumin supplementation on matrix metallopeptidase 13 and cartilage oligomeric matrix protein in women with knee osteoarthritis: a clinical controlled study
Physical medicine
Physical medicine
پژوهشي
Research
<span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Introduction: </span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">This study aimed to investigate the effect of resistance training and nano-curcumin supplementation on matrix metallopeptidase 13 (MMP13) and cartilage oligomeric matrix protein (COMP) in patients with knee osteoarthritis.</span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Materials and Methods: </span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">In this open-label parallel randomized trial study 40 women aged between 45-60 years with knee osteoarthritis (OA) were randomly divided into the control, resistance training, nano-curcumin supplementation, and resistance training + nano curcumin supplementation groups. Socio-demographic characteristics, anthropometric and clinical parameters of the patients (WOMAC test) were collected at the beginning and end of the study. The levels of MMP 13 and COMP in the synovial fluid were measured with a human-specific ELISA kit. </span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Results: </span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Resistance training, supplement intake, and training/supplementation did not significantly change the synovial levels of COMP and MMP 13. Compared with the control group, WOMAC scores were significantly higher in the intervention groups (P = 0.038)</span></span><span dir="RTL" lang="FA" style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">. </span></span><span style="font-size:12.0pt"><span style="font-family:"Times New Roman",serif"></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times="">Conclusion:</span></span></b><span style="font-size:12.0pt"><span new="" roman="" style="font-family:" times=""> Resistance training and nano-curcumin by changing the WOMAC scores of patients with osteoarthritis can have a beneficial effect on improving the condition of these patients.</span></span></span></span></span></span><br>
Nano-curcumin, MMP13, Resistance exercises, Cartilage oligomeric matrix protein
61
70
http://jbrms.medilam.ac.ir/browse.php?a_code=A-10-633-1&slc_lang=en&sid=1
Sadegh
Cheragh-Birjandi
s_birjanadi2001@yahoo.com
10031947532846005114
10031947532846005114
Yes
Department of Sport Science, Bojnourd Branch, Islamic Azad University, Bojnourd, Iran
Maryam
Baghernejad
baghernejad_maryam@yahoo.com
10031947532846005115
10031947532846005115
No
Department of Sport Science, Islamic Azad University, Bojnourd Branch, Bojnourd, Iran
Farideh
Haghighi
farideh.haghighi.1351@gmail.com
10031947532846005116
10031947532846005116
No
Department of Sport Science, Islamic Azad University, Bojnourd Branch, Bojnourd, Iran
Reza
Ganji
10031947532846005117
10031947532846005117
No
Department of Orthopedic Surgery, North Khorasan University of Medical Sciences, Bojnurd, Iran
Hasan
Saadati
10031947532846005118
10031947532846005118
No
Department of Epidemiology and Biostatistics, School of Health, North Khorasan University of Medical Sciences, Bojnurd, Iran
Mohammadreza
Jafari
jafariMR@mums.ac.ir
10031947532846005119
10031947532846005119
No
Department of Pharmaceutical Nanotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran