Journal of Basic Research in Medical Sciences

en Effect of Resistance Exercises and Nano-Curcumin Supplementation on Matrix Metallopeptidase 13 and Cartilage Oligomeric Matrix Protein in Women with Knee Osteoarthritis: A Clinical Controlled Study Physical medicine Physical medicine پژوهشي Research Introduction: This study aimed to investigate the effect of resistance training and nano-curcumin supplementation on matrix metallopeptidase 13 (MMP13) and cartilage oligomeric matrix protein (COMP) in patients with knee osteoarthritis. Materials and Methods: In this open-label parallel randomized trial study 40 women aged between 45-60 years with knee osteoarthritis (OA) were randomly divided into the control, resistance training, nano-curcumin supplementation, and resistance training + nano curcumin supplementation groups. Socio-demographic characteristics, anthropometric and clinical parameters of the patients (WOMAC test) were collected at the beginning and end of the study. The levels of MMP 13 and COMP in the synovial fluid were measured with a human-specific ELISA kit. Results: Resistance training, supplement intake, and training/supplementation did not significantly change the synovial levels of COMP and MMP 13. Compared with the control group, WOMAC scores were significantly higher in the intervention groups (P = 0.038). Conclusion: Resistance training and nano-curcumin by changing the WOMAC scores of patients with osteoarthritis can have a beneficial effect on improving the condition of these patients.   Nano-curcumin, MMP13, Resistance exercises, Cartilage oligomeric matrix protein 61 70 http://jbrms.medilam.ac.ir/browse.php?a_code=A-10-633-1&slc_lang=en&sid=1 Sadegh Cheragh-Birjandi s_birjanadi2001@yahoo.com 10031947532846007629 10031947532846007629 Yes Department of Sport Science, Bojnourd Branch, Islamic Azad University, Bojnourd, Iran Maryam Baghernejad baghernejad_maryam@yahoo.com 10031947532846007630 10031947532846007630 No Department of Sport Science, Islamic Azad University, Bojnourd Branch, Bojnourd, Iran Farideh Haghighi farideh.haghighi.1351@gmail.com 10031947532846007631 10031947532846007631 No Department of Sport Science, Islamic Azad University, Bojnourd Branch, Bojnourd, Iran Reza Ganji 10031947532846007632 10031947532846007632 No Department of Orthopedic Surgery, North Khorasan University of Medical Sciences, Bojnurd, Iran Hasan Saadati 10031947532846007633 10031947532846007633 No Department of Epidemiology and Biostatistics, School of Health, North Khorasan University of Medical Sciences, Bojnurd, Iran Mohammadreza Jafari jafariMR@mums.ac.ir 10031947532846007634 10031947532846007634 No Department of Pharmaceutical Nanotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran