en Professional Health Professional Health پژوهشي Research <span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times="">Introduction: </span></b><span new="" roman="" style="font-family:" times="">This study aimed to evaluate the effect of 12 weeks of interval resistance training with different intensities (low, medium and high) on bone morphogenetic protein 2 (BMP-2), <a name="_Hlk123662338">bone morphogenetic protein </a>4 (BMP-4) and insulin resistance in obese men.</span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times="">Materials and Methods: </span></b><span new="" roman="" style="font-family:" times="">Forty-four obese not trained men, after determining 1RM and based on anthropometric characteristics were divided into the control, low-intensity interval resistance training, medium-intensity interval resistance training, high-intensity interval resistance training groups (in each group, n=11). The protocol of interval resistance training includes 8 movements which were periodic and in different intensities in the form of 3 Set 10 repetitions with 80% 1 RM, rest between sets active, and with 20% intensity and the number of repetitions 15 in the high-intensity group, in the medium intensity group in the form of 3 sets 13 repetitions with 60% RM, resting active sets with 20% intensity and number 15 repetitions and in the low-intensity group in the form of 3 sets of 20 repetitions with 40% 1 RM, rest between sets was active with 20% intensity and the number of repetitions was 15. The first fasting blood sample was obtained 48 hours before and the second blood sample was collected 48 hours after a twelve-week training period. Then the measurements were performed.</span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times="">Results: </span></b><span new="" roman="" style="font-family:" times="">The 12 weeks of interval resistance training with different intensities in the training groups led to a significant decrease in BMP-2 and insulin resistance compared to the control group (P < 0.001) but for BMP-4 these decreases were not significant (P = 0.055).</span></span></span></span></span><br> <b><span style="font-size:11.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">Conclusion: </span></span></span></b><span style="font-size:11.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">The study showed that different intensities of resistance interval training, especially moderate and high intensity training, can decrease the BMP-2, BMP-4 levels and improve insulin resistance.</span></span></span> Interval resistance training, Obesity, Adipokine, Insulin resistance 51 60 http://jbrms.medilam.ac.ir/browse.php?a_code=A-10-650-1&slc_lang=en&sid=1 Mitra Sobhanipoor Sobhanipoor.mit.gmail.com 10031947532846007626 10031947532846007626 No Department of Sport Sciences, Kish International Campus, University of Tehran, Kish, Iran Reza Nouri nuri_r7@ut.ac.ir 10031947532846007627 10031947532846007627 Yes Department of Sport Sciences, Kish International Campus, University of Tehran, Kish, Iran Abbasali Gaeini aagaeini@yahoo.com 10031947532846007628 10031947532846007628 No Department of Exercise Physiology, University of Tehran, Tehran, Iran