Journal of Basic Research in Medical Sciences

en Effect of Six Weeks Endurance Training on Some Hemodynamic Factors in High-fat Diet-Fed Male Rats Physiology Physiology پژوهشي Research <div style="text-align: justify;">Introduction: Hypertension is a pivotal modifiable risk factor for global cardiovascular diseases and premature mortality, often associated with a high-fat diet. This study aimed to explore the impact of endurance training on selected hemodynamic factors in rats subjected to a high-fat diet. Material & Methods: In this experimental research, 21 male Wistar rats (weighing 200-250 g) were randomly assigned to three groups: high-fat diet (HF), normal diet (C), and high-fat diet with endurance training (HF+T), each comprising seven rats. The HF and HF+T groups were exposed to a high-fat diet (60% calories from fat) for 12 weeks. Subsequently, the HF+T group underwent a six-week, five-sessions-per-week endurance training program. Cardiac parameters were recorded using physiography, and data analysis was performed with SPSS software version 24, utilizing one-way ANOVA. Results: The one-way ANOVA results showed no significant difference between groups in heart rate (p=0.143). However, systolic blood pressure was significantly higher in the HF+T group compared to C (p=0.001) and HF (p=0.045) groups. The HF group also exhibited significantly elevated systolic blood pressure compared to the C group (p=0.044). Additionally, diastolic blood pressure was significantly higher in both the HF (p=0.021) and HF+T (p=0.009) groups compared to the C group. Conclusion: This study suggests that a high-fat diet, particularly when combined with endurance training, leads to an increase in blood pressure in rats compared to those fed a normal diet, emphasizing the complex relationship between diet, exercise, and cardiovascular health. The findings underscore the importance of understanding these interactions for comprehensive cardiovascular risk management. The identified hemodynamic changes contribute valuable insights for future interventions aimed at mitigating the impact of high-fat diets on cardiovascular health.</div> Hemodynamics, Exercise Training, Blood Pressure Regulation 81 90 http://jbrms.medilam.ac.ir/browse.php?a_code=A-10-662-1&slc_lang=en&sid=1 Najmeh Arabnejad arabnejadnajmeh827@gmail.com 10031947532846006921 0009-0003-3550-7653 No Department of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran Farshad Ghazalian phdghazalian@gmail.com 10031947532846006922 10031947532846006922 Yes Department of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran Hamid Najafipour najafipour@yahoo.co.uk 10031947532846006923 10031947532846006923 No Cardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran Hossein Abed Natanzi abednazari@gmail.com 10031947532846006924 10031947532846006924 No Department of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran