Journal of Basic Research in Medical Sciences

en The Effect of Endurance Training on The Serum and Cardiac Levels of Malondialdehyde in the High Fat Fed Male Rats Physiology Physiology پژوهشي Research Introduction: Malondialdehyde (MDA) is known as an important biomarker for assessing oxidative stress, which exert many pathological effects. The present study sought to investigate the effect of endurance training on the serum and cardiac levels of malondialdehyde (MDA) and lipid profile in the high fat fed male rats. Materials and Methods: For the 21 male Wistar rats (weighing 200-250g) randomly assigned in three equal groups including the control (C; received normal diet), 60% high-fat diet (HF), and 60% HF + endurance training group (HFE). The HF and HFE groups received 60% calories from fat for 12 weeks. Subsequently, endurance training program performed for six weeks (5 session per week) by the HFE group. Following completing intervention, blood and heart tissue samples collected, and the MDA and lipid profile were measured. Data were analyzed by SPSS-24 software, using one-way ANOVA test. Results: Serum MDA in the C and HFE groups was significantly lowered compared to the HF group (P < 0.05). Cardiac MDA also represented a significant decrease in the C and HFE groups compared to the HF group (P < 0.05).  Moreover, endurance training result in significant improvement in the lipid profile compared to the HF group (P < 0.05). Conclusion: It seems that exercise training can be considered as an effective strategy for ameliorate the pathological effect of high fat feeding, partly exerted by downregulation of serum and cardiac MDA levels and the lipid profile improvement.   High fat diet, Endurance training, Malondialdehyde 69 76 http://jbrms.medilam.ac.ir/browse.php?a_code=A-10-662-2&slc_lang=en&sid=1 Najmeh Arabnejad najmeharabnejad@yahoo.com 10031947532846007606 10031947532846007606 No Department of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran Farshad Ghazalian phdghazalian@gmail.com 10031947532846007607 10031947532846007607 Yes Department of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran Hamid Najafipour najafipour@yahoo.co.uk 10031947532846007608 10031947532846007608 No Cardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran Hossein Abed Natanzi abednazari@gmail.com 10031947532846007609 10031947532846007609 No Department of Physical Education and Sport Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran