en Physiology Physiology پژوهشي Research <div style="text-align: justify;"><span style="font-size:9pt"><span minion="" pro="" style="font-family:"><b>Introduction</b>: The combined use of methadone and exercise training holds promise for promoting health. This study investigates the impact of resistance and aerobic training in conjunction with methadone consumption on lipid profiles and C-reactive protein (CRP) levels in addicted men.</span></span><br> <span style="font-size:9pt"><span minion="" pro="" style="font-family:"><b>Materials & Methods</b>: Ninety addicted men (mean age 36.82 &plusmn; 4.32 years) undergoing prison treatment were randomly assigned to six groups (n=15 each): control, narcotics anonymous (NA), aerobic training + methadone, aerobic training + methadone reduction, resistance training + methadone, resistance training + methadone reduction. The 12-week exercise program, conducted thrice weekly, included aerobic training (4-8 sets, 3 minutes each, at 80-90% maximum heart rate on the ergometer bike) and resistance training (12 repetitions, 3 sets, at 70-85% of one repetition maximum). Blood samples collected pre- and post-intervention measured CRP and blood lipids using specialized kits. Data were analyzed with SPSS software, employing multiple analysis of variance (MANOVA) and Tukey&#39;s post hoc test (P<0.05).</span></span><br> <span style="font-size:9pt"><span minion="" pro="" style="font-family:"><b>Results</b>: High-density lipoprotein (HDL) levels significantly increased in trained groups compared to the control (P<0.001). Moreover, trained groups exhibited significant decreases in low-density lipoprotein (LDL), triglycerides, total cholesterol, and CRP compared to the control group (P<0.05). Importantly, aerobic training was more effective than resistance training in improving the studied variables.</span></span><br> <span style="font-size:9pt"><span minion="" pro="" style="font-family:"><b>Conclusion</b><b><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times="">: </span></span></b>Exercise training, particularly aerobic training with methadone ingestion, yields positive effects, including reduced CRP levels and improved lipid profiles in addicted men. Exercise training with methadone reduction may be considered for empowering individuals with addiction issues.<span lang="FA" dir="RTL" style="font-family:"Times New Roman",serif"></span></span></span></div> Exercise, Lipids, C-reactive Protein, Methadone, Substance-Related Disorders 18 32 http://jbrms.medilam.ac.ir/browse.php?a_code=A-10-459-6&slc_lang=en&sid=1 Rasoul Chegol m.gholami@srbiau.ac.ir 10031947532846006908 10031947532846006908 No Department of Physical Education and Sport Sciences, Faculty of Literature, Humanities and Social Sciences, Science and Research Branch, Islamic Azad university, Tehran, Iran Mandana Gholami m.gholami@srbiau.ac.ir 10031947532846006909 10031947532846006909 Yes Department of Physical Education and Sport Sciences, Faculty of Literature, Humanities and Social Sciences, Science and Research Branch, Islamic Azad university, Tehran, Iran Hasan Matinhomaee hasanmatinhomaee@yahoo.com 10031947532846006910 10031947532846006910 No Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran Hossein Abed Natanzi abednazari@gmail.com 10031947532846006911 10031947532846006911 No Department of Physical Education and Sport Sciences, Faculty of Literature, Humanities and Social Sciences, Science and Research Branch, Islamic Azad university, Tehran, Iran Farshad Ghazalian phdghazalian@gmail.com 10031947532846006912 10031947532846006912 No Department of Physical Education and Sport Sciences, Faculty of Literature, Humanities and Social Sciences, Science and Research Branch, Islamic Azad university, Tehran, Iran