en Biochemistry Biochemistry مقالات مروری Narrative review <br> <span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times="">Introduction:</span></b><span new="" roman="" style="font-family:" times=""> Blood coagulation is an important physiological process in maintaining homeostasis that causes blood to clot. The two main components of the hemostasis process are fibrinolysis and coagulation and influenced by many factors including physical activity and diet. This study aims to evaluate systematic review on the response of the coagulation system and Fibrolytic Factors to Exercise and <i>Saffron</i>. </span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times="">Materials and Methods:</span></b><span new="" roman="" style="font-family:" times=""> Search for studies on the response of coagulation and fibrinolytic factors to exercise and <i>saffron</i> extract in the reputable databases Springer, Hindawi, PubMed, Google Scholar, Scopus, SID and ISC using the keyword Exercise Training and <i>Saffron</i>, platelet count (plt), fibrinogen level, relative activated thromboplastin time (PTT) and prothrombin time (PT) and plasminogen inhibitor-activating antigen (PAI-1), activating antigen tissue plasminogen (tPA), tPA activity and D-dimer were performed. </span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times="">Results:</span></b><span new="" roman="" style="font-family:" times=""> In studies related to <i>saffron</i> extract, its beneficial effects were observed during long-term interventions. However, <i>saffron</i> consumption during the short-term had no effect on coagulation factors. Also, in short-term aerobic and resistance training studies, some studies reported a transient improvement in coagulation indices. Both long-term aerobic and resistance training help to maintain of coagulation homeostasis. </span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times="">Conclusion:</span></b><span new="" roman="" style="font-family:" times=""> Exercise and <i>saffron</i> and its effective substances on the coagulation and fibrinolysis processes in healthy people and in some diseases (such as myocardial infarction and diabetes) have benefits.</span></span></span></span></span><br> <br> &nbsp; Homeostasis, Exercise, Saffron, Coagulation factors 49 58 http://jbrms.medilam.ac.ir/browse.php?a_code=A-10-441-8&slc_lang=en&sid=1 Narges Laghaei n.laghaei@gmail.com 10031947532846007573 10031947532846007573 No Ph.D Student Department of Exercise Physiology, Kermanshah Branch, Islamic Azad University, Kermanshah, Iran Mehran Ghahramani Mehran.physiology@gmail.com 10031947532846007574 10031947532846007574 Yes Department of Exercise Physiology, Kermanshah Branch, Islamic Azad University, Kermanshah, Iran