en Medical physiology Medical physiology پژوهشي Research <span style="font-size:11pt"><span style="line-height:normal"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times="">Introduction: </span></b><span new="" roman="" style="font-family:" times="">Despite careful control of environmental factors, there is a wide variety of interpersonal muscle-induced muscle damage. Genetic changes can also be important in determining susceptibility to injury. Weightlifting is one of the most successful Iranian sports teams in Olympics; so, the aim of this study was the investigation of the relationship between ACE I/D gene polymorphism rs4646994 and incidence and severity of sport injuries in Iranian </span><span new="" roman="" style="font-family:" times="">male elite</span><span new="" roman="" style="font-family:" times=""> weightlifters.</span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times="">Materials and Methods: </span></b><span new="" roman="" style="font-family:" times="">The study was cross-sectional research that conducted in 2022. The statistical population consisted of male elite weightlifters from Isfahan consisting of 31 athletes who all were investigated as sample. A questionnaire was used to collect the injuries data. Saliva samples were taken from all subjects and DNA was extracted and genotyped by using real-time polymerase chain reaction (real time-PCR). Chi-square and regression tests were used to analyze the data. Significance level was also considered at P < 0.05.</span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times="">Results: </span></b><span new="" roman="" style="font-family:" times="">There was a significant difference in the incidence of injuries in different genotypes. ID genotype (59.4%) had the highest incidence of injury in compare with DD (23.2%) and II (17.4%) genotypes (&chi;² = 21.47, P = 0.001). Also, there was a significant difference in the severity of injuries in different genotypes (&chi;² =15.59, P = 0.049); but there was no relationship between genotype and incidence and the severity of sports injuries in selected Iranian elite male weightlifters (P = 0.715).</span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times="">Conclusion: </span></b><span new="" roman="" style="font-family:" times="">The results showed differences in the incidence and severity of sport injuries in different genotypes, hence it would be important in the prediction injury risk in weightlifters.</span></span></span></span><br> &nbsp; Sports Genomics, Sport Injuries, Weightlifters, Elite 62 73 http://jbrms.medilam.ac.ir/browse.php?a_code=A-10-396-4&slc_lang=en&sid=1 Mohammad Reza Batavani babaei@iut.ac.ir 10031947532846007555 10031947532846007555 Yes Center of Physical Education, Isfahan University of Technology, Isfahan 84156-83111, Iran Forogh Zalaki Badil Foroghza67@gmail.com 10031947532846007556 10031947532846007556 No Sport Sciences College, Safahan Non-Governmental Higher Education Institute, Isfahan, Iran Vahid Zolaktaf v.zalaktaf@spr.ui.ac.ir 10031947532846007557 10031947532846007557 No Department of sport Injuries and therapeutic exercise, Faculty of Exercise Sciences, University of Isfahan, Isfahan, Iran