en Physiology Physiology پژوهشي Research <div style="text-align: justify;"><span style="font-size:9pt"><span minion="" pro="" style="font-family:"><b>Introduction</b>: Myonectin is a key player in mediating lipid and glucose metabolism, and exercise training positively influences it by upregulating this myokine. However, the impact of different exercise regimens on myonectin levels is not well understood. This study aims to investigate the effects of three weeks of circuit resistance training on serum myonectin levels and lipid profiles in young men.</span></span><br> <span style="font-size:9pt"><span minion="" pro="" style="font-family:"><b>Material & Methods</b>: Twenty sedentary young males (average age: 23.6 &plusmn; 3.2 years) participated, randomly assigned to circuit resistance training (n=10) and control (n=10) groups. Circuit resistance training, comprising nine sessions over three weeks with nine exercises per session at 60% of one-repetition maximum (1RM), was conducted. The control group maintained their daily routine. Blood samples, collected 48 hours post-training, underwent serum myonectin and lipid profile analysis using specialized kits. SPSS software version 24, ANCOVA tests (p < 0.05), were used for data analysis.</span></span><br> <span style="font-size:9pt"><span minion="" pro="" style="font-family:"><b>Results</b>: The study revealed a significant increase in serum myonectin levels in the trained group compared to controls (p = 0.027). Additionally, the trained group exhibited a significant reduction in cholesterol and an increase in high-density lipoprotein (HDL) levels compared to controls (p < 0.05). Triglyceride and low-density lipoprotein (LDL) levels did not significantly change in the trained group compared to controls (p > 0.05).</span></span><br> <span style="font-size:9pt"><span minion="" pro="" style="font-family:"><b>Conclusion</b><b><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times="">: </span></span></b>This study demonstrates that short-term circuit resistance training (three weeks) significantly improves the lipid profile in sedentary subjects. The positive effect is partially attributed to the upregulation of myonectin levels induced by the training regimen.<span lang="FA" dir="RTL" style="font-family:"Times New Roman","serif""></span></span></span></div> Exercise Training, Myokines, Lipid Profile 1 8 http://jbrms.medilam.ac.ir/browse.php?a_code=A-10-709-1&slc_lang=en&sid=1 Amirsam Heidarpour Ghiasi jafarheidarpour@gmail.com 10031947532846006865 0009-0002-0603-4087 No Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran Hamid Agha-alinejad halinejad@modares.ac.ir 10031947532846006866 10031947532846006866 Yes Department of Physical Education & Sport Sciences, Faculty of Humanities, Tarbiat Modares University, Tehran, Iran Maghsoud Peeri m.peeri@iauctb.ac.ir 10031947532846006867 10031947532846006867 No Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran