en پژوهشي Research <span style="font-size:11pt"><span style="line-height:150%"><span calibri="" style="font-family:"><b><span style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">Introduction: </span></span></span></b><span style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">&nbsp;</span></span></span></span></span></span><span style="font-size:9pt"><span minion="" pro="" style="font-family:">Coronary artery bypass surgery (CABG) is a common procedure for patients with coronary artery disease. This study aimed to investigate the effect of selected physical exercises on the expression of FGF-2 and VEGF-A in patients post-CABG.</span></span><br> <span style="font-size:9pt"><span minion="" pro="" style="font-family:"><b>Material & Methods</b><b><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times="">: </span></span></b>In this semi-experimental study, 20 male patients from Afshar Hospital (Yazd City) who had undergone CABG were selected and randomly divided into two groups: a combined training group and a control group. The combined training group performed an 8-week program consisting of endurance training (15-20 minutes at 50-60% of HRmax) and resistance training (10-20 minutes, including three upper limb and two lower limb movements, each with three sets of 10 repetitions at 30-60% of 1RM), conducted three times per week. Gene expression of Fibroblast Growth Factor 2 (FGF-2) and Vascular Endothelial Growth Factor A (VEGF-A) was measured using Real-Time PCR. Data were analyzed using paired t-tests and one-way ANOVA with a significance level set at P<0.05.</span></span><br> <span style="font-size:9pt"><span minion="" pro="" style="font-family:"><b>Results</b><b><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times="">: </span></span></b>An increase in the expression of VEGF and FGF-2 genes was observed in the combined training group post-test compared to pre-test (p=0.019). Additionally, there was a significant difference in VEGF gene expression between the control and training groups (p=0.016). Significant differences were also found in FGF-2 expression between the combined exercise group and both the healthy control and patient control groups (p=0.001 for both).</span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span calibri="" style="font-family:"><span style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">&nbsp;</span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span calibri="" style="font-family:"><b><span style="font-size:12.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times="">Conclusion:&nbsp;</span></span></span></b></span></span></span><span style="font-size:9pt"><span minion="" pro="" style="font-family:">The results suggest that combined exercises may enhance physiological adaptations and improve the functional capacity of the heart and vessels in CABG patients by increasing growth factor expression.</span></span><br> <br> &nbsp; The results suggest that combined exercises may enhance physiological adaptations and improve the functional capacity of the heart and vessels in CABG patients by increasing growth factor expression. 56 65 http://jbrms.medilam.ac.ir/browse.php?a_code=A-10-694-2&slc_lang=en&sid=1 Maryam Monjezi marya731@yahoo.com 10031947532846006853 0009-0006-4854-5562 No Department of Sport Physiology, Ayatollah Amoli Branch, IslamicAzad University, Amol, Iran Alireza Barari alireza54.barari@gmail.com 10031947532846006854 10031947532846006854 Yes 1 Department of Sport Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran Ahmad Abdi a.abdi58@gmail.com 10031947532846006855 10031947532846006855 No Department of Sport Physiology Ayatollah Amoli Branch Islamic Azad University Amol, Iran