en Neurology Neurology پژوهشي Research <span style="font-size:9pt"><span minion="" pro="" style="font-family:"><b>Introduction</b>: Strokes rank among the leading causes of death and disability worldwide, with acute ischemic stroke (AIS) on the rise in Iran. Thrombolytic drugs constitute a primary treatment for ischemic stroke. However, due to limited studies in Iran, there exists hesitation among physicians regarding their administration. This study aims to assess the efficacy of these drugs on AIS patients.</span></span><br> <span style="font-size:9pt"><span minion="" pro="" style="font-family:"><b>Methods</b><b><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times="">: </span></span></b>In a clinical trial, 80 patients with ischemic stroke were divided into treatment and control groups. Both groups were assessed upon admission and 72 hours later using the National Institutes of Health Stroke Scale (NIHSS) and the Modified Rankin Scale (mRS) scores at discharge. The treatment group received Alteplase (0.9mg/kg), while the control group received standard care. Statistical analysis was performed using SPSS 20.</span></span><br> <span style="font-size:9pt"><span minion="" pro="" style="font-family:"><b>Results</b><b><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times="">: </span></span></b>The mean NIHSS &plusmn; SD scores at admission and 72 hours later in the treatment group were 10.0&plusmn;3.51 and 4.55&plusmn;8.75, respectively, compared to 8.53&plusmn;3.52 and 7.88&plusmn;9.21 in the control group, showing a significant difference in favor of the treatment group (P < 0.001). Similarly, the mean mRS&plusmn; SD score in the treatment group was 1.68&plusmn;1.79, significantly lower than the control group&#39;s 3.15&plusmn;1.61 (P < 0.001).</span></span><br> <span style="font-size:9pt"><span minion="" pro="" style="font-family:"><b>Conclusion</b><b><span style="font-size:11.0pt"><span new="" roman="" style="font-family:" times="">: &nbsp;</span></span></b>Intravenous Alteplase administration proved effective in treating patients with ischemic stroke, significantly reducing neurological complications and disabilities compared to standard medical care.</span></span> Cerebrovascular Disorders, Stroke, Tissue Plasminogen Activator, Alteplase, National Institutes of Health Stroke Scale 62 69 http://jbrms.medilam.ac.ir/browse.php?a_code=A-10-41-4&slc_lang=en&sid=1 Milad MohamadYari 10031947532846006752 10031947532846006752 Yes Student research committee, Ilam university of Medical Sciences, Ilam, Iran Aryoobarzan Rahmatian 10031947532846006753 10031947532846006753 No Department of Neurology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran Monireh Azizi 10031947532846006754 10031947532846006754 No Department of Anatomy, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran Khairollah Asadollahi 10031947532846006755 10031947532846006755 No Department of Social Medicine, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran